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Updated: Feb 3, 2026
07:39
Facile Synthesis of Worm-like Micelles by Visible Light Mediated Dispersion Polymerization Using Photoredox Catalyst
Published on: June 8, 2016
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Multifunctional approaches utilizing polymeric micelles to circumvent multidrug resistant tumors
Siddharth S Kesharwani1, Shamandeep Kaur2, Hemachand Tummala1
1Department of Pharmaceutical Sciences, College of Pharmacy & Allied Health Professions, South Dakota State University, Brookings, SD, 57007, USA.
Colloids and Surfaces. B, Biointerfaces
|October 24, 2018
Summary
Overcoming chemotherapy resistance in cancer is crucial. Polymeric micelles (PMs) offer a nanotechnology solution, enhancing drug delivery and efficacy through multifunctional, stimuli-responsive approaches.
Area of Science:
- Oncology
- Nanotechnology
- Materials Science
Background:
- Chemotherapy efficacy is limited by multiple drug resistance (MDR).
- Existing strategies to overcome MDR are often insufficient or only studied in vitro.
- Nanotechnology, particularly polymeric micelles (PMs), presents innovative solutions for cancer therapy and diagnosis.
Purpose of the Study:
- To review polymeric micelles (PMs) as a drug delivery system for overcoming cancer drug resistance.
- To explore multifunctional and stimuli-sensitive approaches utilizing PMs to combat MDR.
- To discuss the preparation, characterization, and clinical trial status of PMs.
Main Methods:
- Review of scientific literature on polymeric micelles in cancer therapy.
- Analysis of copolymer types used in PM formulation.
- Discussion of stimuli-responsive mechanisms (pH, temperature, reduction) and combination therapies.
Main Results:
- Polymeric micelles enhance drug solubility, permeability, and bioavailability.
- Multifunctional PMs can be designed for targeted delivery and controlled release.
- Various stimuli-sensitive and combination strategies show promise in overcoming MDR.
Conclusions:
- Polymeric micelles are a promising nanotechnology for improving chemotherapy efficacy.
- Multifunctional and stimuli-responsive PMs offer advanced strategies to combat drug resistance in cancer.
- Further clinical investigation of PM-based therapies is warranted.
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