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Related Experiment Video

Updated: Feb 3, 2026

Unilateral Pyramidotomy of the Corticospinal Tract in Rats for Assessment of Neuroplasticity-inducing Therapies

Unilateral Pyramidotomy of the Corticospinal Tract in Rats for Assessment of Neuroplasticity-inducing Therapies

Published on: December 15, 2014

Modified Constraint-Induced Movement Therapy for persons with unilateral upper extremity amputation: A case report.

Anne E McEnerney Edmondson¹, Jill M Cancio², Kathleen E Yancosek¹

¹Center for the Intrepid, Department of Rehabilitation Medicine, Brooke Army Medical Center, JBSA Ft. Sam Houston, TX, USA.

Journal of Hand Therapy : Official Journal of the American Society of Hand Therapists

|October 25, 2018

Summary

Modified Constraint-Induced Movement Therapy (mCIMT) improved functional prosthetic device use in two individuals with upper extremity amputation. This novel approach shows promise for enhancing rehabilitation outcomes in amputee care.

Keywords:

Amputation Constraint-induced movement therapy Rehabilitation Upper extremity amputation

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Area of Science:

Rehabilitation Medicine
Prosthetics and Orthotics
Neurorehabilitation

Background:

High rates of prosthetic device abandonment exist for individuals with upper extremity (UE) amputation.
Modified Constraint-Induced Movement Therapy (mCIMT) is under-utilized in UE amputation rehabilitation despite its success in stroke patients.

Observation:

This study presents an mCIMT intervention for prosthetic device training in two cases of unilateral UE amputation.
The intervention involved a standard rehabilitation program combined with a 3-week home-based mCIMT program (3 hours/day, 5 days/week).

Findings:

Both cases demonstrated increased functional use of their prosthetic UE device, as measured by the Activities Measure for Upper Limb Amputees (AM-ULA).
While AM-ULA scores indicated meaningful improvement, other measures (Disabilities of the Arm, Shoulder, and Hand; Trinity Amputation and Prosthesis Experience Scales-Revised) yielded mixed results.

Implications:

This is the first reported use of mCIMT in a unilateral UE amputee rehabilitation program.
The findings suggest mCIMT may be a valuable therapeutic approach to improve prosthetic device utilization and functional outcomes in individuals with UE amputation.