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Updated: Feb 3, 2026
08:41
Unilateral Pyramidotomy of the Corticospinal Tract in Rats for Assessment of Neuroplasticity-inducing Therapies
Published on: December 15, 2014
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Modified Constraint-Induced Movement Therapy for persons with unilateral upper extremity amputation: A case report
Anne E McEnerney Edmondson1, Jill M Cancio2, Kathleen E Yancosek1
1Center for the Intrepid, Department of Rehabilitation Medicine, Brooke Army Medical Center, JBSA Ft. Sam Houston, TX, USA.
Summary
Modified Constraint-Induced Movement Therapy (mCIMT) improved functional prosthetic device use in two individuals with upper extremity amputation. This novel approach shows promise for enhancing rehabilitation outcomes in amputee care.
Area of Science:
- Rehabilitation Medicine
- Prosthetics and Orthotics
- Neurorehabilitation
Background:
- High rates of prosthetic device abandonment exist for individuals with upper extremity (UE) amputation.
- Modified Constraint-Induced Movement Therapy (mCIMT) is under-utilized in UE amputation rehabilitation despite its success in stroke patients.
Observation:
- This study presents an mCIMT intervention for prosthetic device training in two cases of unilateral UE amputation.
- The intervention involved a standard rehabilitation program combined with a 3-week home-based mCIMT program (3 hours/day, 5 days/week).
Findings:
- Both cases demonstrated increased functional use of their prosthetic UE device, as measured by the Activities Measure for Upper Limb Amputees (AM-ULA).
- While AM-ULA scores indicated meaningful improvement, other measures (Disabilities of the Arm, Shoulder, and Hand; Trinity Amputation and Prosthesis Experience Scales-Revised) yielded mixed results.
Implications:
- This is the first reported use of mCIMT in a unilateral UE amputee rehabilitation program.
- The findings suggest mCIMT may be a valuable therapeutic approach to improve prosthetic device utilization and functional outcomes in individuals with UE amputation.
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