Related Experiment Video
Updated: Feb 3, 2026
Chemical Dimerization-Induced Protein Condensates on Telomeres
Published on: April 12, 2021
The effect of DNA backbone on the triplet mechanism of UV-induced thymine-thymine (6-4) dimer formation
Xingyong Wang1,2, Haibo Yu3,4,5
1School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW, 2522, Australia. xingyong@uow.edu.au.
Abstract:
Density functional theory calculations were carried out to investigate the formation mechanism of the thymine-thymine (6-4) dimer ((6-4)TT), which is one of the main DNA lesions induced by ultraviolet radiation and is closely related to skin cancers. The DNA backbone was found to have nonnegligible effects on the triplet reaction pathway, particularly the reaction steps involving substantial base rotations. The mechanism for the isomerization from (6-4)TT to its Dewar valence isomer (DewarTT) was also explored, confirming the necessity of absorbing a second photon. In addition, the solvation effects were examined and showed considerable influence on the potential energy surface. Graphical Abstract DFT calculations on the influence of DNA backbone on the mechanism of UV-induced thymine-thymine (6-4) dimer formation.
More Related Videos
11:26Integrating a Triplet-triplet Annihilation Up-conversion System to Enhance Dye-sensitized Solar Cell Response to Sub-bandgap Light
Published on: September 12, 2014
10:36Visualization of UV-induced Replication Intermediates in E. coli using Two-dimensional Agarose-gel Analysis
Published on: December 21, 2010
Related Concept Videos
02:27DNA Base Pairing
01:16The DNA Helix
02:05DNA as a Genetic Template
01:44Complementary DNA
01:31Mechanism of Lamellipodia Formation
01:39Mechanism of Filopodia Formation
Their main function is to guide migrating cells during normal tissue morphogenesis or cancer metastasis by recognizing and making initial contacts with the extracellular matrix. However, they can also act as stationary cell anchors or help to establish communication...