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Serotonin Selective Reuptake Inhibitors (SSRIs) and Stroke.

F Chollet1,2, J Rigal3,4, P Marque4,5

  • 1Neurology Department, Hôpital Pierre-Paul Riquet, Centre Hospitalier Universitaire de Toulouse, Toulouse, France. fchperso@gmail.com.

Current Neurology and Neuroscience Reports
|October 25, 2018
PubMed
Summary
This summary is machine-generated.

Selective serotonin reuptake inhibitors (SSRIs) show promise in improving functional recovery after stroke, even in non-depressed patients. Evidence suggests a favorable safety profile and benefit/risk ratio when administered for three months post-stroke.

Keywords:
Brain plasticityIschaemic strokeNeuroprotectionPost-stroke depressionRecovery from strokeSSRIs

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Clinical Neurology

Background:

  • Growing interest in selective serotonin reuptake inhibitors (SSRIs) post-stroke.
  • Increased understanding of post-stroke depression.
  • Emerging evidence on SSRIs' role in functional recovery for non-depressed individuals.

Purpose of the Study:

  • To review the current evidence on SSRIs for functional recovery after stroke.
  • To assess the efficacy and safety of SSRIs in both depressed and non-depressed stroke patients.

Main Methods:

  • Review of basic science and preclinical data.
  • Analysis of positive clinical trials and meta-analyses of stroke patient data.
  • Evaluation of safety data in post-stroke populations.

Main Results:

  • SSRIs demonstrate a capacity to enhance functional recovery in non-depressed stroke patients.
  • Evidence supports a 3-month administration period for optimal recovery.
  • SSRIs exhibit highly favorable safety conditions and a positive benefit/risk ratio in post-stroke patients.

Conclusions:

  • SSRIs represent a promising therapeutic option for improving stroke recovery.
  • Further large-scale studies are warranted to confirm these findings.
  • The use of SSRIs post-stroke, particularly in non-depressed patients, warrants continued investigation.