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A Scalable Model to Study the Effects of Blunt-Force Injury in Adult Zebrafish
Published on: May 31, 2021
Management of Blunt Cerebrovascular Injury
David K Stone1, Vyas T Viswanathan1, Christina A Wilson2
1Department of Neurology, University of Florida, 1149 Newell Dr., PO Box 100236, Gainesville, FL, 32610, USA.
Insights
Early diagnosis and treatment of blunt cerebrovascular injury (BCVI) are crucial for preventing stroke. Prompt screening and antithrombotic therapy significantly reduce stroke risk in affected patients.
Area of Science:
- Neurology
- Vascular Surgery
- Trauma Care
Background:
- Blunt cerebrovascular injury (BCVI) is a significant risk factor for stroke, with 10-40% of untreated patients experiencing this complication.
- A majority of patients with BCVI do not initially present with stroke symptoms, making early detection critical.
- The risk of stroke is highest within the first 7 days of injury, peaking within the first 24 hours.
Purpose of the Study:
- To provide an updated summary of BCVI diagnosis, prevention, and treatment strategies.
- To guide clinicians in the early identification and management of BCVI to prevent associated stroke.
- To highlight the importance of timely intervention in reducing stroke incidence.
Main Methods:
- Review of current literature and clinical guidelines on BCVI.
- Emphasis on computed tomography (CT) angiography as the primary screening tool.
- Discussion of diagnostic criteria and grading of BCVI severity.
Main Results:
- Computed tomography (CT) angiography is the preferred screening method for BCVI.
- Antithrombotic therapy is the primary treatment, demonstrating safety and efficacy in trauma patients.
- Endovascular intervention may be considered for carefully selected patients.
- Early screening and treatment are essential for stroke prevention in BCVI.
Conclusions:
- A high index of suspicion and emergent screening are vital for identifying BCVI.
- Screening should be considered for all patients with injuries warranting neck or chest CT scans.
- Treatment decisions are guided by the injury grade, with early antithrombotic therapy being effective and safe.
Purpose Of Review:
This review provides an updated summary of blunt cerebrovascular injury (BCVI) to guide clinicians in its early diagnosis and prevention and treatment of stroke associated with such injury.
Recent Findings:
Untreated BCVI causes stroke in 10-40% of patients, but more than half will not present with stroke symptoms initially. Risk of stroke is highest in the first 7 days, with a peak in the first 24 h. Computed tomography (CT) angiography is currently the screening modality of choice, although digital subtraction angiography may still be required in some cases. Antithrombotic therapy is the mainstay of treatment and has proven safety in trauma patients. In carefully selected patients, endovascular intervention may also be beneficial. BCVI is a potentially preventable cause of stroke. A high index of suspicion is needed as emergent screening during initial evaluation can provide a window for stroke prevention. Screening all patients with injuries that would otherwise prompt CT scans of the neck or chest is recommended. Treatment is guided by grade of injury. Early treatment with antithrombotics has been shown to be both effective and safe.
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