Related Experiment Video
Updated: Feb 3, 2026

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
Published on: December 7, 2021
Mutation analysis of 13 RM Y-STR loci in Han population from Beijing of China
Li Yuan1,2, Wen Chen3, Dong Zhao3
1Shanghai Key Laboratory of Forensic Medicine, Academy of Forensic Science, Ministry of Justice, PR, China, Shanghai, 200063, People's Republic of China. yuanliwcy@126.com.
Abstract:
Two five-color fluorescence multiplex amplification systems of 13 Y chromosome short tandem repeat (Y-STR) loci (DYF387S1, DYF399S1, DYF403S1a/b, DYF404S1, DYS449, DYS518, DYS526a/b, DYS547, DYS570, DYS576, DYS612, DYS626, and DYS627) have been designed. A study was conducted measuring the mutation rates of the 13 Y-STRs in 501 father-son pairs of Han origin in Beijing, China. Among 7515 allele transmissions in 501 father-son pairs, 75 single-step and 2 two-step mutations were observed. Two father-son pairs had mutations at two different loci in 13 Y-STRs. The estimated mutation rates ranged from 2.00 × 10-3 (95% CI 1.00 × 10-4 to 1.11 × 10-2) for the DYF387S1, DYF403S1b, DYS526a, and DYS449 loci to 4.59 × 10-2 (95% CI 2.93 × 10-2 to 6.81 × 10-2) for the DYF399S1 locus. The average mutation rate is 1.02 × 10-2 (95% CI 8.10 × 10-3 to 1.28 × 10-2). Among these Y-STR markers, only DYF399S1, DYS627, DYF403S1a, DYS547, DYS612, and DYS626 had mutation rates higher than 1.00 × 10-2.
Related Concept Videos
Mutations
Mutations
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
Mutation, Gene Flow, and Genetic Drift
Viral Mutations
Analysis of Population Pharmacokinetic Data
Conservation of Small Populations

