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Sleep Architecture Changed Without RBD in Patients With FTDP-17
Jia Liu1, Shuqin Zhan1, Chaoyang Huang1
1Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Summary
Sleep disturbances in frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) appear early, affecting sleep architecture even before symptoms arise. Polysomnography revealed reduced sleep efficiency and disrupted sleep cycles in affected individuals.
Area of Science:
- Neuroscience
- Sleep Medicine
- Genetics
Background:
- Frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) is a genetic neurodegenerative disorder.
- Sleep disturbances are common in neurodegenerative diseases, but their early manifestations in FTDP-17 are not well understood.
Purpose of the Study:
- To investigate sleep disorder features using polysomnography (PSG) in a Chinese pedigree with FTDP-17.
- To identify sleep architecture alterations in both symptomatic and presymptomatic stages of FTDP-17.
Main Methods:
- Standard polysomnography (PSG) and hypnogram analysis were performed on five individuals from an FTDP-17 pedigree (two symptomatic, three presymptomatic).
- PSG data were compared with 9 patients with Parkinson disease (PD) and 11 control subjects.
Main Results:
- Sleep architecture is significantly affected in the presymptomatic stage of FTDP-17, with notable reductions in total sleep time and sleep efficiency.
- Hypnogram analysis revealed decreased sleep efficiency and disrupted cyclic sleep organization in individuals with FTDP-17.
- Rapid eye movement sleep behavior disorder was not observed in this FTDP-17 cohort.
Conclusions:
- Sleep architecture alterations occur early in FTDP-17, potentially preceding clinical parkinsonism.
- Pathological lesions in the striatum and brainstem may underlie the observed sleep disturbances in FTDP-17.
- Further research is needed to elucidate the precise mechanisms driving these sleep alterations.
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