Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

True Stress and True Strain01:28

True Stress and True Strain

848
Engineering stress is calculated as the load divided by the original, undeformed cross-sectional area. It approximates a material under load. This approximation is especially relevant post-yield in ductile materials. Though engineering stress-strain diagrams are often used for their convenience and accessibility, they can sometimes fall short in accuracy, particularly when dealing with large strain values.
In contrast, true stress offers a more precise portrayal. It is computed by dividing the...
848
Biological Effects of Radiation02:59

Biological Effects of Radiation

17.9K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
17.9K
Higher Mental Functions of Brain: Learning and Memory01:26

Higher Mental Functions of Brain: Learning and Memory

2.1K
Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or...
2.1K
Machines01:19

Machines

579
Machines are complex structures consisting of movable, pin-connected multi-force members that work together to transmit forces. One example of a machine is the cutting plier, which is used to cut wires by applying forces to its handles. When equal and opposite forces are exerted on the handles of the cutting plier, they cause the cutting edges to come together and apply equal and opposite reaction forces on the wire, which are greater than the applied forces.
A free-body diagram of the...
579
Radiation: Applications01:17

Radiation: Applications

1.8K
The average temperature of Earth is the subject of much current discussion. Earth is in radiative contact with both the Sun and dark space; it receives almost all its energy from the radiation of the Sun and reflects some of it into outer space. Dark space is very cold, about 3 K, so Earth radiates energy into it. For instance, heat transfer occurs from soil and grasses, the rate of which can be so rapid that frost can occur on clear summer evenings, even in warm latitudes.
The average...
1.8K
Absorption of Radiation01:05

Absorption of Radiation

1.3K
The rate of heat transfer by emitted radiation is described by the Stefan-Boltzmann law of radiation:
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Beyond TIR: the impact of technology on glucose variability in a cohort of preschool children with T1D.

Diabetology & metabolic syndrome·2026
Same author

Critical Review of Cataractogenesis and Lens Contouring in Radiation Oncology.

Advances in radiation oncology·2026
Same author

Life Detection in the Martian Subsurface: Advancements in Microbial Metabolic Research under Mars Laboratory and Field-Analog Conditions since Viking.

Astrobiology·2026
Same author

Strengthening Clinical Nurses' Research Capacity: A Scoping Review of Factors That Influence Nurses' Engagement in Clinical Research.

Journal of clinical nursing·2026
Same author

The preoperative temporal bone CT: a mnemonic for reducing surgical risk.

Frontiers in radiology·2026
Same author

Screening practices for diabetic peripheral neuropathy in pediatric type 1 diabetes: a nationwide survey by the ISPED Diabetes Study Group.

Acta diabetologica·2026

Related Experiment Video

Updated: Feb 3, 2026

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
08:17

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

16.2K

Distinguishing True Progression From Radionecrosis After Stereotactic Radiation Therapy for Brain Metastases With

Luke Peng1, Vishwa Parekh2, Peng Huang3

  • 1Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD.

International Journal of Radiation Oncology, Biology, Physics
|October 25, 2018
PubMed
Summary

Radiomics shows promise in distinguishing treatment effects from true progression in brain metastases after stereotactic radiosurgery (SRS). A radiomics model achieved an AUC of 0.81, outperforming human review in this diagnostic challenge.

More Related Videos

Machine Learning Algorithms for Early Detection of Bone Metastases in an Experimental Rat Model
07:15

Machine Learning Algorithms for Early Detection of Bone Metastases in an Experimental Rat Model

Published on: August 16, 2020

7.5K
Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
08:54

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Published on: May 8, 2018

15.0K

Related Experiment Videos

Last Updated: Feb 3, 2026

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
08:17

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

16.2K
Machine Learning Algorithms for Early Detection of Bone Metastases in an Experimental Rat Model
07:15

Machine Learning Algorithms for Early Detection of Bone Metastases in an Experimental Rat Model

Published on: August 16, 2020

7.5K
Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
08:54

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Published on: May 8, 2018

15.0K

Area of Science:

  • Neuro-oncology
  • Medical Imaging Analysis
  • Radiomics

Background:

  • Distinguishing treatment effect from true progression after stereotactic radiosurgery (SRS) for brain metastases is challenging.
  • Conventional imaging often fails to differentiate these conditions, impacting patient management.
  • Radiomics offers a novel approach to enhance diagnostic accuracy using quantitative imaging features.

Purpose of the Study:

  • To develop and validate a radiomics-based prediction model for diagnosing treatment effect after SRS for brain metastases.
  • To compare the performance of the radiomics model against expert neuroradiologist assessment.

Main Methods:

  • A cohort of patients treated with SRS for brain metastases who underwent resection or had spontaneous regression was analyzed.
  • Radiomic features were extracted from preoperative MRI (T1 postcontrast and T2-FLAIR) scans.
  • An IsoSVM classifier was trained and validated using cross-validation techniques.

Main Results:

  • An optimized radiomics model achieved an area under the curve (AUC) of 0.81 with 65.38% sensitivity and 86.67% specificity.
  • The radiomics model demonstrated superior diagnostic performance compared to neuroradiologist review (73% classification rate, 19% specificity).

Conclusions:

  • Radiomics holds significant potential for differentiating treatment effects from true progression in brain metastases post-SRS.
  • The developed radiomics model shows promising performance, warranting further validation in independent datasets.
  • This approach could aid in guiding patient management and evaluating novel treatment interventions.