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Related Experiment Video

Updated: Feb 3, 2026

Procurement and Decellularization of Rat Hindlimbs Using an Ex Vivo Perfusion-Based Bioreactor for Vascularized Composite Allotransplantation

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Published on: June 9, 2022

Vascular Bed Molecular Profiling by Differential Systemic Decellularization In Vivo.

Aida Serra¹, Xavier Gallart-Palau¹, Jung Eun Park¹

¹From the School of Biological Sciences, Nanyang Technological University, Singapore (A.S., X.G.-P., J.E.P., J.P.T., S.K.S.).

Arteriosclerosis, Thrombosis, and Vascular Biology

|October 26, 2018

Summary

Researchers developed a new method to analyze molecular interactions in vascular beds, aiding the study of vascular endothelial dysfunction in diseases. This technique allows for system-wide proteomic profiling of the vasculature in vivo.

Keywords:

capillary beds endothelial cells glycocalyx proteomics smooth muscle

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Decellularization and Recellularization of Whole Livers

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Published on: February 4, 2011

Area of Science:

Vascular Biology
Proteomics
Disease Pathogenesis

Background:

Vascular endothelial dysfunction is implicated in numerous human diseases.
Understanding its molecular basis in vivo has been challenging due to limitations in system-wide analysis methods.
Previous research lacked suitable techniques for comprehensive vascular bed biology studies.

Purpose of the Study:

To develop a novel method for investigating vascular endothelial dysfunction pathogenesis.
To enable system-wide analyses of molecular interactions within murine vascular beds.
To study interactions between the endothelial glycocalyx, endothelial cells, and smooth muscle cells.

Main Methods:

Developed a technique using whole-body differential perfusion with increasing detergent concentrations.
Applied differential systemic decellularization in vivo combined with proteomics.
Selective solubilization of vascular bed layers: endothelial glycocalyx, endothelial cells, and smooth muscle cells.

Main Results:

Enabled quantitative proteomic profiling of vascular beds throughout the body in rodents.
Successfully applied to characterize molecular events in lipopolysaccharide-induced vascular pathology.
Demonstrated system-wide molecular characterization of vascular bed proteomes.

Conclusions:

Differential systemic decellularization in vivo allows comprehensive molecular characterization of vascular bed proteomes.
This method advances the understanding of vascular endothelial dysfunction pathogenesis and progression.
Applicable to a wide range of disease settings involving vascular pathology.