Related Experiment Video

Updated: Feb 3, 2026

Isolation of Intrapulmonary Artery and Smooth Muscle Cells to Investigate Vascular Responses
07:56

Isolation of Intrapulmonary Artery and Smooth Muscle Cells to Investigate Vascular Responses

Published on: June 8, 2022

4.8K

Vascular Smooth Muscle Remodeling in Conductive and Resistance Arteries in Hypertension

Isola A M Brown1, Lukas Diederich2, Miranda E Good1

  • 1From the Robert M. Berne Cardiovascular Research Center (I.A.M.B., M.E.G., L.J.D., S.A.M., B.E.I.).

Arteriosclerosis, Thrombosis, and Vascular Biology
|October 26, 2018
PubMed

Insights

Hypertension causes dangerous vascular remodeling in arteries, increasing cardiovascular disease risk. This review explores vascular smooth muscle cell changes and genetic factors, offering insights into new hypertension treatments.

Area of Science:

  • Cardiovascular Medicine
  • Hypertension Research
  • Vascular Biology

Background:

  • Cardiovascular disease (CVD) is a major global health burden, causing over 17.3 million deaths annually.
  • Hypertension is a primary risk factor for CVD, leading to significant morbidity and mortality.
  • Current hypertension therapies are only partially effective, highlighting the need for improved treatments.

Purpose of the Study:

  • To review the clinical implications of vascular remodeling in hypertension.
  • To compare vascular smooth muscle cell remodeling in conductive versus resistance arteries.
  • To discuss genetic factors influencing vascular smooth muscle cell function in hypertension and explore future therapeutic targets.

Main Methods:

  • Literature review focusing on vascular remodeling in hypertension.
  • Comparative analysis of vascular smooth muscle cell changes in different arterial types.
  • Exploration of genetic associations and pharmacological targets for hypertension treatment.

Main Results:

  • Hypertension is characterized by pathological vascular remodeling, increasing peripheral vascular resistance.
  • Distinct structural and functional changes occur in vascular smooth muscle cells of conductive and resistance arteries.
  • Genetic factors play a role in vascular smooth muscle cell dysfunction in hypertensive individuals.

Conclusions:

  • Understanding vascular remodeling and genetic factors is crucial for developing effective hypertension therapies.
  • Targeting vascular smooth muscle cell remodeling presents a promising avenue for future pharmacological interventions.
  • Further research is needed to translate these findings into improved clinical outcomes for hypertensive patients.

Keywords:
hypertensionmyocardial infarctionsmooth musclevascular remodeling

More Related Videos

Isolation of Murine Coronary Vascular Smooth Muscle Cells08:24

Isolation of Murine Coronary Vascular Smooth Muscle Cells

Published on: May 30, 2016

14.8K
A Model of Reverse Vascular Remodeling in Pulmonary Hypertension Due to Left Heart Disease by Aortic Debanding in Rats07:41

A Model of Reverse Vascular Remodeling in Pulmonary Hypertension Due to Left Heart Disease by Aortic Debanding in Rats

Published on: March 1, 2022

3.4K

Related Concept Videos

Resistance and Conductance01:25

Resistance and Conductance

A conductor's DC resistance at a given temperature is influenced by its resistivity, length, and cross-sectional area. Resistivity is an inherent property of the conductor material, with annealed copper serving as the international standard for measurement. For instance, the resistivity of hard-drawn aluminum at 20 degrees Celsius is 61% of the standard conductivity of annealed copper.
Various factors impact the resistance of a conductor. Spiraling in stranded conductors increases their...
515
Vascular Resistance01:20

Vascular Resistance

Vascular resistance is a critical concept in understanding blood flow dynamics in the circulatory system. It refers to the resistance that blood encounters as it flows through the blood vessels. This resistance is a key factor in determining blood pressure and cardiac workload.
The primary determinants of vascular resistance are vessel diameter, blood viscosity, and vessel length. Among these, vessel diameter plays the most significant role due to the fourth power relationship described by...
10.9K
Functions of Smooth Muscles01:23

Functions of Smooth Muscles

Smooth muscles are an important type of muscle tissue that plays a vital role in the involuntary movements of internal organs. For example, they help regulate the movement of food through the gut and the flow of blood through the circulatory system.
Function of visceral smooth muscles
Visceral smooth muscle is found in the walls of all hollow organs, except the heart, and is a key player in the involuntary movements that drive the functioning of these internal organs. This tissue is arranged in...
3.4K
Smooth Muscle Contraction01:25

Smooth Muscle Contraction

Smooth muscle contraction is a complex process vital for various bodily functions, from maintaining blood vessel tension to facilitating the movement of food through the digestive tract. Unlike striated muscles, smooth muscle contraction begins more slowly and lasts longer.
The onset of contraction is triggered by an increase in calcium ions within the sarcoplasm, similar to the process in striated muscle. However, smooth muscles have a relatively smaller reservoir of the sarcoplasmic...
7.8K
Structure and Organization of Smooth Muscles01:13

Structure and Organization of Smooth Muscles

Smooth muscle tissue is a type of muscle tissue that can be found lining various vital organs in the human body, including the lungs, blood vessels, digestive tract, and respiratory tract. This type of tissue is responsible for regulating the movements of these organs, playing crucial roles in the functioning of various systems, including the vascular, digestive, respiratory, and urinary systems.
Structure of smooth muscle cell
Smooth muscle cells are spindle-shaped with tapering ends and a...
8.7K
Nucleosome Remodeling02:54

Nucleosome Remodeling

Nucleosomes are the basic units of chromatin compaction. Each nucleosome consists of the DNA bound tightly around a histone core, which makes the DNA inaccessible to DNA binding proteins such as DNA polymerase and RNA polymerase. Hence, the fundamental problem is to ensure access to DNA when appropriate, despite the compact and protective chromatin structure.
Nucleosome remodeling complex
Eukaryotic cells have specialized enzymes called ATP-dependent nucleosome remodeling enzymes. These enzymes...
11.2K