Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Trait and State Self-Esteem02:08

Trait and State Self-Esteem

11.5K
The term self-esteem is often used generically, to refer to how people feel about themselves. However, according to research, there are three distinct constructs that should not be used interchangeably (Brown & Marshall, 2006). 
11.5K
Polygenic Traits01:18

Polygenic Traits

69.1K
When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
69.1K
Multiple Allele Traits01:49

Multiple Allele Traits

38.1K
The Concept of Multiple Allelism
38.1K
Traits and States01:17

Traits and States

558
Personality traits represent consistent patterns in behavior, thoughts, and emotions, reflecting an individual's tendencies across various situations. For example, extraversion, a well-known trait, manifests in individuals as talkative, energetic, and enthusiastic behaviors. These traits are stable over time, offering a reliable framework for predicting how people might act in different contexts. However, they do not define every moment of an individual's life. In contrast to traits,...
558
X-linked Traits01:19

X-linked Traits

58.6K
In most mammalian species, females have two X sex chromosomes and males have an X and Y. As a result, mutations on the X chromosome in females may be masked by the presence of a normal allele on the second X. In contrast, a mutation on the X chromosome in males more often causes observable biological defects, as there is no normal X to compensate. Trait variations arising from mutations on the X chromosome are called “X-linked”.
58.6K
Trait Centrality01:21

Trait Centrality

193
Trait centrality refers to the degree to which a particular characteristic influences the overall impression of an individual. Some traits exert a disproportionately strong impact on perception, shaping how people interpret other attributes of a person. Solomon Asch first systematically studied this phenomenon in 1946.Asch’s Experiment on Trait CentralityAsch's seminal study demonstrated the centrality of certain traits through a controlled experiment. Participants were presented with a...
193

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic and sociodemographic factors associated with trajectories of physical and mental health multimorbidity in a South Asian cohort in the UK: A multistate modelling analysis.

PLoS medicine·2026
Same author

Trajectories of child emotional and behavioural difficulties before and during the COVID-19 pandemic in a longitudinal UK cohort.

JCPP advances·2026
Same author

Data-Driven Decision Support in Obesity Management Commission: enabling more equitable and personalized obesity care.

Nature medicine·2026
Same author

Combining polygenic risk scores to understand genetic liability to physical-mental health multimorbidity in UK Biobank.

Human molecular genetics·2026
Same author

Genetic determinants of childhood blood pressure and heart rate in relation to adult health outcomes: the consortium of childhood blood pressure.

European heart journal·2026
Same author

Extreme heat impacts on daily life and adaptive behaviours captured through lived experience.

Environmental research letters : ERL [Web site]·2026

Related Experiment Video

Updated: Feb 3, 2026

Genotypic Inference of HIV-1 Tropism Using Population-based Sequencing of V3
11:10

Genotypic Inference of HIV-1 Tropism Using Population-based Sequencing of V3

Published on: December 27, 2010

12.8K

Genotype-Based Recall Studies in Complex Cardiometabolic Traits.

Paul W Franks1,2,3,4, Nicholas J Timpson5

  • 1Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden (P.W.F.).

Circulation. Genomic and Precision Medicine
|October 26, 2018
PubMed
Summary

Genotype-based recall (GBR) studies efficiently investigate genetic links to cardiometabolic health. This review explores GBR designs, enhancing genetic association studies and Mendelian randomization applications.

Keywords:
clinical trialenvironmental exposuregenetic association studiesrandom allocationresearch design

More Related Videos

A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo
11:17

A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo

Published on: August 11, 2018

12.5K
Examining Recall Memory in Infancy and Early Childhood Using the Elicited Imitation Paradigm
06:35

Examining Recall Memory in Infancy and Early Childhood Using the Elicited Imitation Paradigm

Published on: April 28, 2016

35.4K

Related Experiment Videos

Last Updated: Feb 3, 2026

Genotypic Inference of HIV-1 Tropism Using Population-based Sequencing of V3
11:10

Genotypic Inference of HIV-1 Tropism Using Population-based Sequencing of V3

Published on: December 27, 2010

12.8K
A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo
11:17

A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo

Published on: August 11, 2018

12.5K
Examining Recall Memory in Infancy and Early Childhood Using the Elicited Imitation Paradigm
06:35

Examining Recall Memory in Infancy and Early Childhood Using the Elicited Imitation Paradigm

Published on: April 28, 2016

35.4K

Area of Science:

  • Genetics
  • Cardiometabolic Health
  • Biostatistics

Background:

  • Genotype-based recall (GBR) studies involve re-contacting individuals with specific genotypes from a larger cohort for detailed investigation.
  • GBR designs offer powerful approaches to study genotype-phenotype associations, environmental exposures, and gene-treatment interactions.

Purpose of the Study:

  • To review existing literature on GBR studies in cardiometabolic health.
  • To explore current GBR methodologies and propose novel designs for enhanced utility.
  • To highlight GBR's potential to augment randomized controlled trials and Mendelian randomization.

Main Methods:

  • Literature review of GBR studies focused on cardiometabolic health outcomes.
  • Analysis of various GBR study designs and their applications.
  • Discussion of potential future directions and integration with basic science.

Main Results:

  • GBR studies are effective in increasing the efficiency of genetic association studies, enabling detailed phenotyping in smaller cohorts.
  • GBR facilitates the investigation of environmental exposures within a Mendelian randomization framework.
  • GBR designs can be applied to interventional trials to examine gene-treatment interactions.

Conclusions:

  • GBR methods offer a valuable tool for advancing cardiometabolic health research.
  • GBR has the potential to enhance randomized controlled trials and provide alternative applications for Mendelian randomization.
  • Integrating GBR with functional and basic science research can deepen our understanding of specific biological pathways and their implications.