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Updated: Feb 3, 2026

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Heart Centers for Women: Historical Perspective on Formation and Future Strategies to Reduce Cardiovascular Disease
Gina P Lundberg1, Laxmi S Mehta2, Rupa M Sanghani3
1Emory University School of Medicine, Atlanta, GA (G.P.L.).
Insights
Heart Centers for Women (HCW) improved cardiovascular disease (CVD) outcomes for women, reducing mortality rates. Further strategies are needed to address persistent disparities and expand the HCW model for equitable care.
Area of Science:
- Cardiology
- Women's Health
- Public Health
Background:
- Cardiovascular disease (CVD) historically had higher mortality rates in women compared to men.
- Limited sex-specific research and awareness contributed to disparities in women's CVD outcomes.
- Heart Centers for Women (HCW) were established to address these critical gaps in care.
Purpose of the Study:
- To evaluate the impact of Heart Centers for Women (HCW) on cardiovascular disease (CVD) outcomes in women.
- To identify persistent disparities in CVD mortality reduction among women.
- To propose new strategies for expanding and improving the HCW model.
Main Methods:
- Analysis of CVD mortality trends in women versus men from 1984 to 2015.
- Review of the role and contributions of Heart Centers for Women (HCW) in addressing sex-specific CVD issues.
- Identification of areas for future development and expansion of the HCW model.
Main Results:
- CVD mortality in women declined below that of men by 2014-2015.
- Increased public and provider awareness of CVD in women has been observed.
- Despite progress, not all women have equally benefited from mortality reductions, indicating ongoing disparities.
Conclusions:
- Heart Centers for Women (HCW) have been instrumental in improving CVD outcomes for women.
- New strategies are required to address remaining disparities and ensure equitable care for all women.
- Future HCW models should incorporate expanded curricula, interdisciplinary collaboration, diverse care approaches, and inclusivity of male providers.
Abstract:
Heart Centers for Women (HCW) developed as a response to the need for improved outcomes for women with cardiovascular disease (CVD). From 1984 until 2012, more women died of CVD every single year in comparison with men. Initially, there was limited awareness and sex-specific research regarding mortality or outcomes in women. HCW played an active role in addressing these disparities, provided focused care for women, and contributed to improvements in these gaps. In 2014 and 2015, death from CVD in women had declined below the level of death from CVD in comparison with men. Even though awareness of CVD in women has increased among the public and healthcare providers and both sex- and gender-specific research is currently required in all research trials, not all women have benefitted equally in mortality reduction. New strategies for HCW need to be developed to address these disparities and expand the current HCW model. The HCW care team needs to direct academic curricula on sex- and gender-specific research and care; expand to include other healthcare professionals and other subspecialties; provide new care models; address diversity; and include more male providers.
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