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Parasite Induced Genetically Driven Autoimmune Chagas Heart Disease in the Chicken Model
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Chagas Cardiomyopathy: An Update of Current Clinical Knowledge and Management: A Scientific Statement From the

Maria Carmo Pereira Nunes, Andrea Beaton, Harry Acquatella

    Circulation
    |October 26, 2018
    PubMed

    Insights

    Chagas disease, caused by Trypanosoma cruzi, is increasingly prevalent in non-endemic areas like the US. Healthcare providers need updated guidance on diagnosing and managing this parasitic infection, especially its cardiac complications.

    Area of Science:

    • Cardiology
    • Infectious Diseases
    • Parasitology

    Background:

    • Chagas disease, caused by Trypanosoma cruzi, is a significant cause of cardiovascular morbidity and mortality.
    • Once considered tropical, it now affects over 300,000 in the US and is rising in non-endemic regions.
    • Urgent need for healthcare systems outside Latin America to recognize, diagnose, and treat Chagas disease.

    Purpose of the Study:

    • Increase global awareness of Chagas disease among healthcare providers.
    • Provide updated information on diagnosis, screening, and treatment of Trypanosoma cruzi infection.
    • Focus on cardiovascular manifestations and management of Chagas cardiomyopathy.

    Main Methods:

    • Commissioned statement by the American Heart Association and Inter-American Society of Cardiology.
    • Summarizes current knowledge and practices in Chagas disease diagnosis and management.
    • Includes quick reference tables for suspected or confirmed cases.

    Main Results:

    • Chagas disease presents significant cardiovascular risks including heart failure, stroke, and arrhythmia.
    • Growing prevalence in the US necessitates improved diagnostic and treatment protocols.
    • Updated guidance is crucial for managing Chagas cardiomyopathy in diverse settings.

    Conclusions:

    • This statement aims to enhance recognition of Chagas cardiomyopathy in low-prevalence areas.
    • Improve the care and management of patients with Chagas heart disease globally.
    • Equip healthcare providers with essential knowledge for Chagas disease patient care.
    Abstract

    Keywords:
    AHA Scientific StatementsAmerican trypanosomiasisChagas diseasecardiac arrhythmiacardiomyopathiesdilated cardiomyopathyheart failurethromboembolism

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