Related Experiment Video
Updated: Feb 3, 2026
10:34
Derivation of a Human Brain Organoid with Microglia Development
Published on: January 17, 2025
2.0K
Development of human electrophysiological brain networks
Paul M Briley1, Elizabeth B Liddle1, Madeleine J Groom1
1Centre for Translational Neuroimaging in Mental Health, Institute of Mental Health, School of Medicine, University of Nottingham , Nottingham , United Kingdom.
Journal of Neurophysiology
|October 26, 2018
Summary
Brain network connectivity, particularly in higher-order cognitive networks like the default mode network (DMN), strengthens through adolescence. This development, measured by magnetoencephalography (MEG), supports improved attention and cognitive coordination in young people.
Area of Science:
- Neuroscience
- Developmental Neuroscience
- Cognitive Neuroscience
Background:
- Human brain function is organized into distinct, interconnected networks.
- Higher-order networks (default mode network, frontoparietal network, salience network) develop through adolescence, unlike mature sensory systems.
- Electrophysiological evidence on adolescent brain network maturation is limited compared to functional MRI (fMRI) studies.
Purpose of the Study:
- To investigate the developmental trajectory of functional brain network connectivity using electrophysiology.
- To compare magnetoencephalography (MEG) findings with existing fMRI data on adolescent brain development.
Main Methods:
- Magnetoencephalography (MEG) recordings were obtained from 48 participants aged 9-25 years at rest.
- Beta-band functional connectivity was analyzed within and between major brain networks (DMN, FPN, SN, visual system).
Main Results:
- Functional connectivity within the DMN, FPN, and SN increases throughout adolescence, reaching adult levels around age 20.
- Connectivity within the visual system matures earlier, by late childhood (around age 14).
- Inter-network connectivity also increases with age, contrary to some fMRI findings.
Conclusions:
- Beta-band oscillations and their coordinated activity within and between higher-order networks mature significantly during adolescence.
- This maturation likely underpins the development of attentional control and integrated cognitive functions in adolescents.
- MEG provides valuable insights into the electrophysiological basis of adolescent brain network development.
Related Concept Videos
02:26Protein Networks
4.5K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.5K
02:26Protein Networks
2.9K
2.9K
02:18Network Covalent Solids
16.2K
Network covalent solids contain a three-dimensional network of covalently bonded atoms as found in the crystal structures of nonmetals like diamond, graphite, silicon, and some covalent compounds, such as silicon dioxide (sand) and silicon carbide (carborundum, the abrasive on sandpaper). Many minerals have networks of covalent bonds.
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
16.2K
01:43Sustainable Development
15.1K
As the human population continues to grow and use resources, we must be mindful of our planet’s natural limits. Sustainable development provides a pathway to maintain and improve human life now while also ensuring that future generations will have the resources that they need. The long-term success of sustainability efforts rests on understanding the interplay between human actions and ecological systems.
15.1K
01:25Network Function of a Circuit
704
Frequency response analysis in electrical circuits provides vital insights into a circuit's behavior as the frequency of the input signal changes. The transfer function, a mathematical tool, is instrumental in understanding this behavior. It defines the relationship between phasor output and input and comes in four types: voltage gain, current gain, transfer impedance, and transfer admittance. The critical components of the transfer function are the poles and zeros.
704
01:19Electrophysiology of Normal Cardiac Rhythm
9.2K
The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase...
9.2K