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Updated: Feb 3, 2026

Working with Human Tissues for Translational Cancer Research
Published on: November 26, 2015
Spermidine reduces cancer-related mortality in humans
Federico Pietrocola1,2, Francesca Castoldi2,3,4,5,6,7,8, Oliver Kepp2,3,4,5,6,7,8
1a Institute for Research in Biomedicine , Barcelona , Spain.
Abstract:
A recent prospective epidemiological study suggested that an increase in the nutritional uptake of the natural polyamine spermidine is associated with reduced overall and cancer-specific mortality. Here, we speculate through which mechanisms spermidine might exert such oncopreventive effects. Abbreviations: ACLY, ATP citrate lyase; ATG, autophagy-related gene; CoA, coenzyme A; NSCLC, non-small cell lung cancer.
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