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Nup2 performs diverse interphase functions in Aspergillus nidulans.

Subbulakshmi Suresh1,2, Sarine Markossian1,3, Aysha H Osmani1

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Nuclear pore complex protein Nup2 is essential for nuclear transport and cell division in Aspergillus nidulans. This study reveals Nup2

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Genetics

Background:

  • The nuclear pore complex (NPC) protein Nup2 has known roles in interphase nuclear transport.
  • In Aspergillus nidulans, Nup2 also bridges NPCs at mitotic chromatin for inheritance to daughter nuclei.
  • This study focuses on the interphase functions of Nup2 in A. nidulans.

Purpose of the Study:

  • To investigate the interphase functions of the NPC protein Nup2 in Aspergillus nidulans.
  • To identify specific nuclear transport and localization roles of Nup2 during the cell cycle.

Main Methods:

  • Analysis of Nup2 deletion mutants (nup2) in A. nidulans.
  • Assessment of nuclear import and accumulation of specific proteins (Mad2, Mlp1, Tho2, Ima1).
  • Investigation of nuclear migration patterns post-mitosis using microtubule cytoskeleton dependence.

Main Results:

  • Nup2 is required for the G1 nuclear accumulation of Mad2, Mlp1, and Tho2.
  • Mlp1 mislocalization contributes to interphase delays in nup2 mutants, partially rescued by Mlp1 re-targeting.
  • Nup2 influences the localization of inner nuclear membrane protein Ima1 and limits post-mitotic nuclear migration.

Conclusions:

  • Nup2 is a multifunctional protein involved in both interphase nuclear transport and mitotic processes in A. nidulans.
  • Nup2's roles include regulating the localization of key nuclear proteins and controlling post-mitotic nuclear positioning.
  • These findings highlight Nup2's critical contributions to nuclear integrity and cell division fidelity.