Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Toxic Reactions: Overview01:26

Toxic Reactions: Overview

2.0K
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
2.0K
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

963
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
963
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

1.5K
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
1.5K
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

620
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
620
Other Pulmonary Disorders01:17

Other Pulmonary Disorders

1.7K
Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
1.7K
Overview of Pulmonary Circulation01:19

Overview of Pulmonary Circulation

3.1K
The pulmonary circulation is a vital system in our body that acts as a bridge between the respiratory and cardiovascular systems. It serves as a transport network for deoxygenated blood from the heart to the lungs and then returns oxygen-rich blood back to the heart.
The process begins with the right ventricle of the heart pumping deoxygenated blood into the pulmonary trunk. This large vessel extends about 5 centimeters before splitting into the left and right pulmonary arteries. These arteries...
3.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Perioperative management of the vulnerable and failing right ventricle.

Perioperative medicine (London, England)·2024
Same author

Issue 3-The occupational burden of respiratory diseases, an update.

Pulmonology·2024
Same author

Differential plasma branched-chain amino acid responses following the consumption of Greek-style yogurt and skimmed milk.

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme·2023
Same author

Differential insecticide resistance in <i>Bemisia tabaci</i> (Hemiptera: Aleyrodidae) field populations in the Punjab Province of Pakistan.

Heliyon·2022
Same author

Pancreas fat quantification with quantitative CT: an MRI correlation analysis.

Clinical radiology·2020
Same author

Molecular characterization of two previously undescribed begomovirus-associated alphasatellite molecules infecting malvaceous species in Cameroon.

Archives of virology·2020
Same journal

Rifamycin-based regimens for preventive treatment in low TB incidence countries.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2026
Same journal

The Kochi Declaration 2024 - A catalyst for global TB elimination through private sector engagement.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2026
Same journal

Preventing lung function decline and pleural thickening after pleural TB: a systematic review.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2026
Same journal

Aircraft contact investigations for TB on domestic and inbound flights to the United States.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2026
Same journal

Treatment outcome of extracorporeal membrane oxygenation in critically ill patients with pulmonary TB.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2026
Same journal

Factors associated with sputum culture positivity of <i>Mycobacterium tuberculosis</i>.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2026
See all related articles

Related Experiment Video

Updated: Feb 3, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
10:44

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

13.8K

Pulmonary toxicity associated with pomalidomide.

S Gajic1, E C Callahan2, J K Brown3

  • 1Department of Medicine.

The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
|October 26, 2018
PubMed
Summary
This summary is machine-generated.

Pomalidomide can cause delayed lung injury, leading to persistent pulmonary fibrosis. While stopping the drug improves symptoms, some lung damage may remain, highlighting a risk of this multiple myeloma treatment.

More Related Videos

Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery
08:17

Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery

Published on: February 20, 2017

15.0K
Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension
10:03

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension

Published on: June 27, 2025

786

Related Experiment Videos

Last Updated: Feb 3, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
10:44

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

13.8K
Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery
08:17

Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery

Published on: February 20, 2017

15.0K
Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension
10:03

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension

Published on: June 27, 2025

786

Area of Science:

  • Pulmonology
  • Oncology
  • Pharmacology

Background:

  • Pomalidomide is a therapeutic agent used in treating multiple myeloma.
  • Pomalidomide has been associated with acute pulmonary toxicity.
  • Pulmonary toxicity from pomalidomide typically improves upon drug discontinuation.

Observation:

  • A 61-year-old male patient on pomalidomide and corticosteroids presented with worsening shortness of breath and severe hypoxemia.
  • Computed tomographic imaging revealed ground glass opacities.
  • The patient experienced clinical improvement after a corticosteroid taper and pomalidomide cessation.

Findings:

  • The patient developed delayed pneumonitis with persistent pulmonary fibrosis.
  • Despite treatment, substantial residual lung fibrosis remained.
  • The clinical course suggests pomalidomide-induced lung injury.

Implications:

  • Pomalidomide can cause delayed and potentially irreversible lung damage.
  • Clinicians should monitor for pulmonary toxicity in patients treated with pomalidomide.
  • Further research into the mechanisms and long-term effects of pomalidomide-induced lung injury is warranted.