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Biomarkers in COPD - Challenging, Real or Illusive
Radostina V Cherneva1, Dimitar T Kostadinov1
1Department of Internal Medicine, St Sofia University Hospital of Respiratory Diseases, Medical University of Sofia, Sofia, Bulgaria.
Folia Medica
|October 26, 2018
Summary
Biomarker research in chronic obstructive pulmonary disease (COPD) faces challenges due to data complexity. Standardization of methods and patient cohorts is crucial for developing validated COPD biomarkers.
Area of Science:
- Respiratory Medicine
- Biomarker Discovery
- Chronic Obstructive Pulmonary Disease (COPD) Research
Background:
- Biomarker research is rapidly advancing in COPD, a major respiratory disease.
- Despite numerous 'omics' studies, fibrinogen is the only European Medicines Agency-validated biomarker.
- Current data complexity from diverse samples and methods hinders practical biomarker application.
Purpose of the Study:
- To review currently validated biomarkers for COPD.
- To highlight the critical need for standardization in biomarker research.
- To address the challenges in selecting appropriate biological samples for COPD pathobiology.
Main Methods:
- Review of existing literature on COPD biomarkers.
- Analysis of data from diverse biological samples and techniques.
- Examination of validation criteria and standardization issues.
Main Results:
- Fibrinogen is the sole validated biomarker by the European Medicines Agency.
- Thousands of studies generate vast, often confusing, biomarker data.
- Lack of homogeneity in patient cohorts and methods complicates interpretation.
Conclusions:
- Validated COPD biomarkers require analysis in accurately described, homogeneous patient cohorts.
- Standardized criteria for tissue sampling, validated kits, and technologies are essential.
- Addressing standardization is key to unlocking the practical value of COPD biomarkers.
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