Related Experiment Video

Updated: Feb 3, 2026

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

19.7K

Resveratrol eliminates cancer stem cells of osteosarcoma by STAT3 pathway inhibition

Lihua Peng1, Dianming Jiang1

  • 1Department of Orthopedics, the First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.

Plos One
|October 26, 2018
PubMed

Insights

Resveratrol effectively targets osteosarcoma stem cells by inhibiting proliferation and tumorigenesis. This natural compound shows promise for osteosarcoma treatment by blocking the JAK2/STAT3 signaling pathway.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Resveratrol exhibits anti-tumor properties across various cancers.
  • The specific impact of resveratrol on osteosarcoma stem cells and its mechanisms are not fully understood.

Purpose of the Study:

  • To investigate the effects of resveratrol on osteosarcoma stem cells.
  • To elucidate the molecular pathways involved in resveratrol's action against osteosarcoma stem cells.

Main Methods:

  • Assessed resveratrol's impact on osteosarcoma cell viability, self-renewal, and tumorigenesis.
  • Investigated the role of cytokines and the JAK2/STAT3 signaling pathway.
  • Examined the effect of exogenous STAT3 activation on resveratrol's efficacy.

Main Results:

  • Resveratrol significantly inhibited osteosarcoma cell viability, self-renewal, and tumorigenesis.
  • Resveratrol demonstrated no significant inhibitory effect on normal osteoblast cells.
  • Resveratrol treatment reduced cytokine synthesis and inhibited JAK2/STAT3 signaling, correlating with decreased CD133 expression.
  • Restoring STAT3 activity diminished resveratrol's cancer stem cell-eliminating effects.

Conclusions:

  • Resveratrol effectively inhibits osteosarcoma cell proliferation and tumorigenesis.
  • The anti-cancer effects are linked to the inhibition of cytokine-mediated JAK2/STAT3 signaling.
  • Resveratrol presents potential as a therapeutic agent for managing osteosarcoma.

More Related Videos

Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells08:52

Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells

Published on: June 13, 2018

9.3K
Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells13:38

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells

Published on: January 18, 2017

12.7K

Related Concept Videos

Feedback Inhibition00:46

Feedback Inhibition

Biochemical reactions are occurring constantly in cells, converting starting substances to different products, usually with the help of enzymes that speed the reactions. Without enzymes, it would take far too long for most reactions to occur to be useful to the cell!
57.1K
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
4.5K
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
6.0K
Adult Stem Cells01:33

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
33.9K
Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
32.4K
C4 Pathway and CAM01:27

C4 Pathway and CAM

Most plants use the C3 pathway for carbon fixation. However, some plants, such as sugar cane, corn, and cacti that grow in hot conditions, use alternative pathways to fix carbon and conserve energy loss due to photorespiration. Photorespiration is the process that occurs when the oxygen concentration is high. Under such conditions, the rubisco enzyme in the Calvin cycle binds O2 instead of CO2, which halts photosynthesis and consumes energy.
C4 Pathway
The C4 pathway is used by plants such as...
49.2K