Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autonomic Nervous System01:22

Autonomic Nervous System

12.8K
The autonomic nervous system (ANS) is a critical component of the peripheral nervous system, primarily responsible for regulating involuntary bodily functions and maintaining homeostasis. It functions in tandem with the central nervous system (CNS) to seamlessly coordinate various physiological processes without the need for conscious control.
The ANS comprises two main divisions: the sympathetic and parasympathetic divisions. These divisions function antagonistically to maintain a dynamic...
12.8K
Autonomic Nervous System: Overview01:26

Autonomic Nervous System: Overview

7.5K
The human nervous system is divided into two main parts: the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS is composed of the brain and spinal cord, while the PNS contains nerve cells, clusters of nerve cells, and the sensory receptors that are outside the CNS. The PNS has two types of nerve cells: sensory (afferent) and motor (efferent). Sensory cells send signals to the CNS from receptors, and motor cells carry signals from the CNS to organs, muscles, and...
7.5K
Disorders of the Autonomic Nervous System01:18

Disorders of the Autonomic Nervous System

1.6K
The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
1.6K
What is a Nervous System?01:25

What is a Nervous System?

104.8K
Overview
104.8K
The Parasympathetic Nervous System01:14

The Parasympathetic Nervous System

115.5K
Overview
115.5K
The Sympathetic Nervous System01:25

The Sympathetic Nervous System

103.6K
Overview
103.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Phoenix criteria for paediatric sepsis: 2 years on.

The Lancet. Child & adolescent health·2026
Same author

Predicting Intensive Care Readmission Among Hospitalized Children.

medRxiv : the preprint server for health sciences·2026
Same author

Identifying a Refractory Shock Phenotype in Pediatric Sepsis Using a Vasoactive-Adjusted Shock Index.

Shock (Augusta, Ga.)·2026
Same author

Night Terrors and Delirium in a Child With Presumed Rapid-Onset Obesity With Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation.

Cureus·2026
Same author

External Validation, Recalibration, and Extension of a Prediction Model of Early Acute Kidney Injury in Critically Ill Children Using Multicenter Data.

Critical care explorations·2026
Same author

External Validation, Molecular Signatures, and Therapeutic Relevance of Pediatric Sepsis-Associated Acute Kidney Injury Subphenotypes.

Critical care medicine·2026

Related Experiment Video

Updated: Feb 3, 2026

Measuring Cardiac Autonomic Nervous System ANS Activity in Toddlers - Resting and Developmental Challenges
08:22

Measuring Cardiac Autonomic Nervous System ANS Activity in Toddlers - Resting and Developmental Challenges

Published on: February 25, 2016

15.9K

Autonomic Nervous System Dysfunction in Pediatric Sepsis.

Colleen M Badke1,2, Lauren E Marsillio1,2, Debra E Weese-Mayer2,3,4

  • 1Division of Critical Care Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, United States.

Frontiers in Pediatrics
|October 26, 2018
PubMed
Summary
This summary is machine-generated.

Autonomic nervous system dysfunction (ANSD) is common in pediatric sepsis, impacting outcomes. Measuring ANS function noninvasively can aid in diagnosis and treatment for critically ill children.

Keywords:
autonomic nervous systemcritical careheart rate variabilityinflammationorgan dysfunctionpediatricssepsis

More Related Videos

Measuring Cardiac Autonomic Nervous System ANS Activity in Children
09:45

Measuring Cardiac Autonomic Nervous System ANS Activity in Children

Published on: April 29, 2013

21.5K
Quantitative Autonomic Testing
11:40

Quantitative Autonomic Testing

Published on: July 19, 2011

58.6K

Related Experiment Videos

Last Updated: Feb 3, 2026

Measuring Cardiac Autonomic Nervous System ANS Activity in Toddlers - Resting and Developmental Challenges
08:22

Measuring Cardiac Autonomic Nervous System ANS Activity in Toddlers - Resting and Developmental Challenges

Published on: February 25, 2016

15.9K
Measuring Cardiac Autonomic Nervous System ANS Activity in Children
09:45

Measuring Cardiac Autonomic Nervous System ANS Activity in Children

Published on: April 29, 2013

21.5K
Quantitative Autonomic Testing
11:40

Quantitative Autonomic Testing

Published on: July 19, 2011

58.6K

Area of Science:

  • Critical Care Medicine
  • Pediatric Sepsis Research
  • Autonomic Nervous System Physiology

Background:

  • The autonomic nervous system (ANS) is crucial for maintaining homeostasis during stress, including sepsis.
  • Autonomic nervous system dysfunction (ANSD) is prevalent in pediatric sepsis and linked to adverse outcomes.
  • Heart rate variability is a key marker for ANS function, inversely correlating with organ dysfunction and mortality.

Purpose of the Study:

  • To review the role of ANS physiology and dysfunction in critical illness, particularly pediatric sepsis.
  • To discuss methods for measuring ANS function noninvasively in the intensive care unit.
  • To explore the diagnostic, prognostic, and therapeutic implications of understanding ANSD in pediatric sepsis.

Main Methods:

  • Literature review of autonomic nervous system function and dysfunction in critical illness.
  • Analysis of studies utilizing heart rate variability and other ANS measures.
  • Discussion of noninvasive monitoring techniques for ANS function in intensive care settings.

Main Results:

  • ANSD is prevalent in pediatric sepsis and associated with poorer outcomes.
  • Measures like heart rate variability, respiratory rate variability, and skin thermoregulation reflect ANS function and predict outcomes.
  • Other ANSD measures such as baroreflex and chemoreflex sensitivity are also linked to critical illness outcomes.

Conclusions:

  • Understanding ANSD is vital for pediatric sepsis management due to its pathophysiological role and prognostic significance.
  • Continuous, noninvasive measurement of ANS function offers potential for improved patient care.
  • Further research into ANSD can inform diagnostic, prognostic, and therapeutic strategies for pediatric sepsis.