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Epstein-Barr Virus-Positive T/NK-Cell Lymphoproliferative Diseases in Chinese Mainland

Junhong Ai1, Zhengde Xie1

  • 1Beijing Key Laboratory of Pediatric Respiratory Infectious Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics (Capital Medical University), Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.

Frontiers in Pediatrics
|October 26, 2018
PubMed

Insights

Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders (EBV+ T/NK LPD) are diverse and affect young people. This review summarizes clinical features of these disorders in Chinese patients.

Area of Science:

  • Hematology
  • Oncology
  • Virology

Background:

  • Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders (EBV+ T/NK LPD) represent a complex group of conditions.
  • These disorders, including chronic active EBV infection (CAEBV) and EBV-associated hemophagocytic lymphohistiocytosis (EBV-HLH), predominantly impact pediatric and young adult populations, often with severe outcomes.

Purpose of the Study:

  • To review and consolidate the clinical characteristics of EBV+ T/NK LPD observed in Chinese patients.
  • To provide a comprehensive overview of the spectrum of these disorders within a specific demographic.

Main Methods:

  • Systematic review of published literature.
  • Analysis of clinical data from Chinese patients diagnosed with EBV+ T/NK LPD.

Main Results:

  • EBV+ T/NK LPD exhibit overlapping clinical, histologic, and immunophenotypic features.
  • The review highlights the specific clinical presentations and variations within the Chinese patient cohort.

Conclusions:

  • Understanding the clinical features of EBV+ T/NK LPD in Chinese patients is crucial for accurate diagnosis and management.
  • Further research into these heterogeneous disorders is warranted to improve patient outcomes.

Keywords:
ChinaEpstein-Barr virusT/natural killer cellclinical featurelymphoproliferative disorder

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