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Related Experiment Video

Updated: Feb 3, 2026

Characterization of Glycoproteins with the Immunoglobulin Fold by X-Ray Crystallography and Biophysical Techniques

Characterization of Glycoproteins with the Immunoglobulin Fold by X-Ray Crystallography and Biophysical Techniques

Published on: July 5, 2018

Biophysical Characterization of CD6-TCR/CD3 Interplay in T Cells.

Marjolein B M Meddens¹, Svenja F B Mennens², F Burcu Celikkol³

¹Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.

Frontiers in Immunology

|October 26, 2018

Summary

This study reveals that CD6 and the T cell receptor (TCR)/CD3 complex form dynamic microclusters during T cell activation. These clusters move towards the immunological synapse center, driven by actin polymerization, highlighting CD6

Keywords:

CD3 CD6 T cell T-cell receptor (TCR)immunological synapse membrane receptor receptor dynamics

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Area of Science:

Immunology
Cell Biology
Biophysics

Background:

T cell activation relies on T cell receptor (TCR) and CD3 complex signaling.
The immunological synapse (IS) is crucial for T cell-APC communication.
CD6 associates with TCR/CD3 but its dynamic role in IS formation is unclear.

Purpose of the Study:

To investigate the dynamic interaction and stability of CD6 with the TCR/CD3 complex during IS formation.
To elucidate the role of CD6 in T cell activation and signaling microcluster dynamics.

Main Methods:

Utilized microscopy techniques with antibody spots and beads for T cell-APC interaction studies.
Employed supported lipid bilayers to analyze receptor dynamics.
Investigated actin polymerization dependence of microcluster transport.

Main Results:

Demonstrated co-localization and recruitment of CD6 with TCR/CD3 into stimulatory clusters on T cells.
Showed that CD6 forms microclusters that co-localize with TCR/CD3 microclusters during IS formation.
Confirmed radial transport of CD6-TCR/CD3 microclusters towards the IS center, dependent on actin polymerization.

Conclusions:

CD6 plays a significant role in T cell activation by forming dynamic microclusters with TCR/CD3.
This study provides novel insights into the dynamic interplay between CD6 and TCR/CD3 during IS formation.
The biophysical methods used are valuable for studying other membrane receptor interactions.