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Updated: Feb 3, 2026
12:20
Use of the Operant Orofacial Pain Assessment Device OPAD to Measure Changes in Nociceptive Behavior
Published on: June 10, 2013
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Pituitary Hormones and Orofacial Pain
Gregory Dussor1, Jacob T Boyd2, Armen N Akopian3,4
1School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX, United States.
Frontiers in Integrative Neuroscience
|October 26, 2018
Summary
Pituitary hormones influence orofacial pain by regulating nociception. This emerging research highlights their potential role in sex-specific pain mechanisms and novel therapeutic strategies.
Area of Science:
- Neuroscience
- Endocrinology
- Pain Research
Background:
- Pituitary hormones regulate nociceptive transmission in orofacial pain.
- Pituitary hormones interact with gonadal hormones, suggesting a role in sex-dependent pain.
- Sex disparities in orofacial pain prevalence may be linked to pituitary hormone involvement.
Purpose of the Study:
- Review clinical conditions with altered pituitary hormone levels and orofacial pain.
- Discuss mechanisms of pituitary hormone regulation of nociception.
- Outline sex-specific regulation of nociception by pituitary hormones.
Main Methods:
- Literature review of clinical and basic research.
- Analysis of pituitary hormone interactions with gonadal hormones.
- Exploration of cell signaling pathways in nociception.
Main Results:
- Pituitary hormones can modulate nociceptive pathways in orofacial pain.
- Evidence suggests pituitary hormones contribute to sex-specific pain mechanisms.
- Alterations in pituitary hormone levels are associated with orofacial pain conditions.
Conclusions:
- Pituitary hormones are a novel target for understanding and treating orofacial pain.
- Understanding sex-specific roles of pituitary hormones is crucial for developing targeted therapies.
- Hormonal therapies may offer new avenues for managing orofacial pain.
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