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Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay

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Published on: March 12, 2018

Metastatic giant cell osteosarcoma in a cat.

Ghasem Farjanikish¹, Omid Dezfoulian¹, Hossein Mohammadi²

¹Department of Pathobiology, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran.

Veterinary Research Forum : an International Quarterly Journal

|October 26, 2018

Summary

A rare feline bone tumor, characterized by giant cells and oval cells, was identified in a Persian cat. Metastasis to the liver and spleen was confirmed, highlighting the aggressive nature of this osseous neoplasm.

Keywords:

Giant cell osteosarcoma Immunohistochemistry Metastasis Persian cat

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Area of Science:

Veterinary Pathology
Comparative Oncology

Background:

A four-year-old Persian cat presented with progressive lameness.
A rigid osseous mass was detected in the left arm.

Observation:

Histopathology revealed two distinct cell populations: multinucleated giant cells and oval cells.
These cells were embedded in a fibro-osseous stroma with lamellar bone trabeculae.
Necropsy showed multiple metastatic nodules in the liver and spleen.

Findings:

Tumor cells infiltrated the liver and spleen, consistent with metastasis.
Neoplastic cells showed no immunoreaction to CD68, desmin, alpha smooth muscle actin, S100, CD20, CD3, and pancytokeratin.
A few cells exhibited vimentin reactivity, suggesting fibroblast-like properties.

Implications:

This case describes a rare, aggressive osseous neoplasm in a feline patient.
The findings contribute to understanding feline bone tumor behavior and metastasis.
Further research may elucidate the specific cell of origin and optimal treatment strategies for such tumors.