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Updated: Feb 3, 2026

A Fluorescence-based Protocol for Preliminary Screening of Protein Synthesis Inhibitors from Natural Sources
Published on: January 27, 2026
Aryne-based strategy in the total synthesis of naturally occurring polycyclic compounds
Hiroshi Takikawa1, Arata Nishii, Takahiro Sakai
1Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan.
Abstract:
The total syntheses of polycyclic natural products by exploiting an aryne as the key reactive species are reviewed. A short introduction summarizes the basic reactivities of aryne species as well as the methods for its generation. In the main part, early examples and the recent reports (mainly 2012-present) on the use of arynes in multistep syntheses are described.
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