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Annotation of Plant Gene Function via Combined Genomics, Metabolomics and Informatics

Annotation of Plant Gene Function via Combined Genomics, Metabolomics and Informatics

Published on: June 17, 2012

GENCODE reference annotation for the human and mouse genomes.

Adam Frankish¹, Mark Diekhans², Anne-Maud Ferreira³

¹European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.

Nucleic Acids Research

|October 26, 2018

Summary

This summary is machine-generated.

The GENCODE consortium provides high-quality gene annotations for human and mouse genomes, essential for advancing genome biology and clinical genomics research. These comprehensive gene descriptions are crucial for accurate data analysis and discovery.

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Area of Science:

Genomics
Bioinformatics
Molecular Biology

Background:

Accurate gene identification is crucial for genome biology and clinical genomics.
The GENCODE consortium has established a 15-year track record of producing reference-quality gene annotations.
High-quality gene annotations serve as a foundational resource for genomic research.

Purpose of the Study:

To describe the GENCODE consortium's efforts in generating and improving gene annotations.
To highlight the collaborative approach involving experimental and computational biology groups.
To detail the methodologies used for creating comprehensive gene annotations.

Main Methods:

Generating primary data and developing bioinformatics tools.
Supporting expert manual gene annotators and automated annotation pipelines.
Utilizing all publicly available data, analysis, and scientific literature for gene characterization.

Main Results:

Production of reference-quality gene annotations for human and mouse genomes.
Continuous improvement and extension of gene annotation datasets.
Identification and characterization of gene loci to the highest standard.

Conclusions:

GENCODE provides essential, high-standard gene annotations for the scientific community.
The consortium's work supports advancements in both fundamental genome biology and clinical applications.
GENCODE annotations are readily accessible through multiple platforms and browsers.