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Metabolic Labeling of Leucine Rich Repeat Kinases 1 and 2 with Radioactive Phosphate
Published on: September 18, 2013
Small leucine rich proteoglycans in host immunity and renal diseases
Wei Zou1, Junhui Wan2, Min Li2
1Department of Infectious Diseases, The 1st Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi, China. ieeeif@hotmail.com.
Abstract:
The small leucine rich proteoglycans (SLRPs), structurally consisting of protein cores and various glycosaminoglycan side chains, are grouped into five classes based on common structural and functional properties. Besides being an important structural component of extracellular matrix (ECM), SLRPs have been implicated in the complex network of signal transduction and host immune responses. The focus of this review is on SLRPs in host immunity. Because host immunity plays an important part in the pathogenesis of renal diseases, the role of SLRPs in this set of diseases will also be discussed.
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