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Related Experiment Video

Updated: Feb 3, 2026

Author Spotlight: Treating Knee Osteoarthritis with Tuina - A New Perspective

Author Spotlight: Treating Knee Osteoarthritis with Tuina - A New Perspective

Published on: January 12, 2024

Advanced Injectable Alternatives for Osteoarthritis.

Şebnem Şahin¹, Süleyman Ali Tuncel², Kouroush Salimi³

¹Department of Nanotechnology and Nanomedicine, Graduate School of Science and Engineering, Hacettepe University, Ankara, Turkey.

Advances in Experimental Medicine and Biology

|October 26, 2018

Summary

Osteoarthritis (OA) treatments are evolving beyond symptom management. This review explores novel injectable therapies, including stem cells and advanced drug delivery systems, offering disease-modifying alternatives to joint replacement surgery.

Keywords:

Cartilage Chondrocytes Chondroitin sulfate Glycosaminoglycan Hyaluronan Osteoarthritis

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Area of Science:

Orthopedics
Regenerative Medicine
Biomaterials Science

Background:

Osteoarthritis (OA) involves progressive joint cartilage degradation, causing pain, stiffness, and disability.
Chondrocyte dysfunction and extracellular matrix (ECM) breakdown drive OA pathogenesis.
Current nonsurgical OA treatments primarily manage symptoms, with limited disease-modifying options.

Purpose of the Study:

To review current and emerging injectable alternatives for osteoarthritis (OA) treatment.
To explore novel therapeutic strategies that modify the natural course of OA.
To provide an overview of options bridging conventional therapies and joint replacement surgery.

Main Methods:

Literature review of nonsurgical osteoarthritis treatments.
Analysis of injectable therapies including hyaluronic acid, cell-based therapies, and platelet-rich plasma.
Examination of advanced delivery systems like hydrogels and nano-carriers for enhanced efficacy.

Main Results:

Injectable therapies offer potential for disease modification in OA.
Stem cell therapies are under investigation for their regenerative capabilities in OA.
Advanced delivery systems can improve the effectiveness of current OA treatments.

Conclusions:

Injectable alternatives represent a promising frontier in osteoarthritis management.
These novel approaches may offer disease-modifying benefits, potentially delaying or avoiding joint replacement surgery.
Further research into stem cells and sophisticated delivery systems is crucial for advancing OA treatment.