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Related Concept Videos

Bone Cells and Tissue01:30

Bone Cells and Tissue

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Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
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Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
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Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts—...
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Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
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A heat engine is a device used to extract heat from a source and then convert it into mechanical work used for various applications. For example, a steam engine on an old-style train can produce the work needed for driving the train.
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Related Experiment Video

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Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering
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Silk Fibroin-Based Scaffold for Bone Tissue Engineering.

Joo Hee Choi1, Do Kyung Kim1, Jeong Eun Song1

  • 1Department of BIN Convergence Technology, Chonbuk National University, Jeonju-si, Jeollabuk-do, South Korea.

Advances in Experimental Medicine and Biology
|October 26, 2018
PubMed
Summary
This summary is machine-generated.

Silk fibroin (SF) shows promise for bone tissue engineering scaffolds due to its biocompatibility and mechanical properties. This review highlights recent advancements in using SF biomaterials for skeletal tissue regeneration.

Keywords:
BiomaterialBone regenerationBone tissue engineeringScaffoldSilk fibroinTissue engineering

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Regenerating damaged skeletal tissues remains a significant challenge in medicine.
  • Scaffold-based tissue engineering offers a promising approach to complement conventional treatments for large bone defects.
  • Silk fibroin (SF) is a biomaterial with favorable properties for bone tissue engineering applications.

Purpose of the Study:

  • To review the recent applications and advancements of silk fibroin (SF) as a biomaterial in bone tissue engineering.
  • To discuss the potential of SF in creating functional environments for skeletal tissue regeneration.

Main Methods:

  • Literature review of recent studies on silk fibroin in bone tissue engineering.
  • Analysis of SF properties relevant to bone regeneration, including mechanical characteristics, biodegradation, and biocompatibility.
  • Exploration of various scaffold fabrication methods for SF.

Main Results:

  • Silk fibroin (SF) possesses unique mechanical properties, a controllable biodegradation rate, and high biocompatibility, making it suitable for bone grafts.
  • SF can be fabricated into diverse scaffold architectures (sponges, mats, hydrogels, films) using various biofabrication techniques.
  • Recent advancements demonstrate the efficacy of SF-based scaffolds in supporting skeletal tissue regeneration.

Conclusions:

  • Silk fibroin (SF) is a versatile and highly effective biomaterial for developing advanced scaffolds in bone tissue engineering.
  • SF-based scaffolds hold significant potential for improving outcomes in treating diseased or damaged skeletal tissues.
  • Continued research into SF biomaterials will likely drive further innovation in regenerative medicine.