Related Experiment Video
Updated: Feb 3, 2026
Uncontrolled Hemorrhagic Shock Modeled via Liver Laceration in Mice with Real Time Hemodynamic Monitoring
Published on: May 21, 2017
[A Case of Anaphylactic Shock Immediately after Administration of Sugammadex]
Abstract:
We experienced a case of 82-years-old-man who developed anaphylactic shock immediately after admin- istration of sugammadex. He was scheduled for ventral hernia surgery. Anesthesia was induced by propofol, rocuronium and remifentanil, and maintained with des- flurane, remifentanil and intermittent rocuronium. Intraoperative course was stable. After the operation, sugammadex was administered. After 3 minutes, hypo- tension with tachycardia developed. We administered ephedrine, but it was not effective. Then, wheal with redness also appeared over the trunk and limbs. We considered anaphylactic shock caused by sugammadex, and immediately administered adrenaline and cortico- steroid. In addition rapid volume load of crystalloid solution 500 ml was given. His hemodynamics recov- ered, and wheal with redness also disappeared gradu- ally. His respiratory state was stable and he was extubated. After administration of methylpredniso- lone, he was transferred to the surgical ward and showed no troubles thereafter. Anaphylaxis caused by sugammadex is a rare event However, considering the high frequency of sugamma- dex use in Japan, we should always keep the possibil- ity of anaphylactic shock caused by sugammadex in mind during daily general anesthetic management.
Related Concept Videos
01:16Shock Waves
When the source's speed approaches the speed of sound, constructive interference between successive wavefronts emitted by the source occurs immediately behind it. Initially, scientists believed that this constructive interference would result in such high...
01:24Blood Pressure Imbalances and Circulatory Shock
Blood Pressure: Hypertension and Hypotension
Normal blood pressure is 120/80 mm Hg. Elevated blood pressure is 120-129/under 80 mm Hg. Hypertension, warranting treatment at 130/80 mm Hg, is often asymptomatic and can lead to severe cardiovascular events, aneurysms, peripheral arterial disease, chronic renal disease, or cardiac...
01:18Additional Routes of Drug Administration
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
01:18Routes of Drug Administration: Enteral
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
Unlike sublingually drugs, drugs that are taken orally pass through the gastrointestinal (GI) tract and get metabolized by the liver. Once metabolized, the drug is absorbed into the systemic circulation, reaching different body parts via the bloodstream. However, while passing through the stomach,...
01:25Routes of Drug Administration: Parenteral
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
01:22Routes of Drug Administration: Overview
Enteral administration refers to drugs absorbed through the gastrointestinal tract. They can be swallowed (perorally), placed under the tongue (sublingually), or on the inner lining of the cheeks (buccally). Perorally administered drugs take time to be absorbed and have a slower onset of action. The rectal route is another form of enteral administration, which allows for...