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Related Experiment Video

Updated: Feb 3, 2026

Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry

Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry

Published on: January 12, 2018

[A man with a red umbilicus].

Simon B Kramer¹, Sadhanna Badeloe^1,2, Willem G Wassenaar³

¹HMC Westeinde, afd. Dermatologie, Den Haag.

Nederlands Tijdschrift Voor Geneeskunde

|October 26, 2018

Summary

This summary is machine-generated.

A pancreas carcinoma metastasis presented as a sore belly button in a 76-year-old man. This rare presentation, known as a Sister Mary Joseph

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Last Updated: Feb 3, 2026

Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry

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Published on: January 12, 2018

Quantification of Lipid Abundance and Evaluation of Lipid Distribution in Caenorhabditis elegans by Nile Red and Oil Red O Staining

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Autofluorescence Imaging to Evaluate Red Algae Physiology

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Published on: February 17, 2023

Area of Science:

Oncology
Dermatology
Gastroenterology

Background:

Metastatic disease can manifest in unusual cutaneous sites.
The umbilicus is a rare but recognized site for metastatic deposits.

Observation:

A 76-year-old male presented with a 3-week history of an erythematous, symptomatic umbilical lesion.
Initial clinical presentation mimicked a localized inflammatory or infectious process.

Findings:

Histopathological examination confirmed metastatic adenocarcinoma.
Elevated Cancer Antigen 19-9 (CA 19-9) levels supported a pancreatic origin.
CT scan revealed a pancreatic mass, consistent with primary carcinoma.

Implications:

Umbilical metastases, or Sister Mary Joseph's nodules, can be an early sign of advanced intra-abdominal malignancy, particularly pancreatic cancer.
This case highlights the importance of considering metastatic disease in the differential diagnosis of umbilical lesions, even in the absence of typical symptoms.
Prompt diagnosis through integrated clinical, radiological, and biochemical evaluation is crucial for patient management and prognosis.