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[Transient erythema after alcohol consumption; a side effect of tacrolimus]
Niels P J de Graaf1,2, Edwin J M van Leent1, Thomas Rustemeyer1
1Amsterdam UMC, locatie VUmc, afd. Dermatologie.
Background:
Transient erythema after alcohol consumption is a side effect of topical tacrolimus use. The clinical picture is characterised by itching, a burning sensation and erythema, often at the site where tacrolimus is applied. The erythema develops shortly after alcohol consumption and disappears after approximately 1 hour.
Case Description:
We are describing a patient who used a 0.1% tacrolimus ointment for periocular eczema and in whom transient erythema developed around the eyes after alcohol consumption.
Conclusion:
The symptoms may be caused by the capsaicin-like effects of both tacrolimus and ethanol. Potential inhibition of aldehyde dehydrogenase by tacrolimus may also play a role. Prophylactic treatment with acetylsalicylic acid before alcohol consumption reduces the symptoms.
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