Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Proteomics01:33

Proteomics

9.8K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
9.8K
Traumatic Memory01:20

Traumatic Memory

583
Emotionally traumatic events often lead to memories that are exceptionally vivid and enduring, sometimes persisting with remarkable clarity throughout an individual's life. A classic example of this phenomenon is a person who survives a car accident. Even years later, they may recall every detail of the event with startling accuracy — the screeching of the tires, the jarring impact, and the acrid smell of burning rubber. Such vividness contrasts sharply with how an individual...
583
Post-traumatic Stress Disorder01:27

Post-traumatic Stress Disorder

558
Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
558
Frustration and Conflict: Approach-Approach, Approach-Avoidance01:20

Frustration and Conflict: Approach-Approach, Approach-Avoidance

533
Frustration occurs when people are obstructed or prevented from achieving a desired goal or fulfilling a perceived need. For example, when someone's input is ignored in a discussion, it can lead to feelings of frustration. Conflict, however, arises from opposing interests, goals, or actions. Conflicts can take various forms based on the nature of these opposing desires or goals.
One common type of conflict is the Approach–Approach Conflict. In this case, a person faces two desirable...
533
Experimental Determination of Chemical Formula02:37

Experimental Determination of Chemical Formula

47.1K
The elemental makeup of a compound defines its chemical identity, and chemical formulas are the most concise way of representing this elemental makeup. When a compound’s formula is unknown, measuring the mass of its constituent elements is often the first step in determining the formula experimentally.
47.1K
Experimental RNAi02:15

Experimental RNAi

7.5K
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
7.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Epinephrine nebulization delays need for life-saving intervention following smoke inhalation in ovine model.

Shock (Augusta, Ga.)·2026
Same author

Selective hemoadsorption of cytokines and platelet-neutrophil complexes mitigates lung microvascular hyperpermeability in an ovine acute lung injury model.

Intensive care medicine experimental·2026
Same author

Sirtuin2 blockade inhibits replication of human immunodeficiency virus-1 and Mycobacterium tuberculosis in macrophages and humanized mice.

Molecular therapy : the journal of the American Society of Gene Therapy·2026
Same author

Hypoxia Rewires Histone Methylation in Glioblastoma Cells via Enzyme Reprogramming Despite Disruption of One-Carbon Metabolism.

Biochemistry·2025
Same author

Integrated molecular and microenvironmental drivers of drug resistance in gastrointestinal cancers: mechanisms, immunotherapy challenges, and precision strategies.

Frontiers in oncology·2025
Same author

Metabolic Tracing of Methyl Donor Utilization in Histone Methylation via Relative Quantification of Isotopomer Distribution Mass Spectrometry.

ACS chemical biology·2025

Related Experiment Video

Updated: Feb 3, 2026

Controlled Cortical Impact Model for Traumatic Brain Injury
05:30

Controlled Cortical Impact Model for Traumatic Brain Injury

Published on: August 5, 2014

29.7K

Proteomic changes in traumatic brain injury: experimental approaches.

James L Sowers1, Ping Wu2, Kangling Zhang3

  • 1MD/PhD Combined Degree Program and The Neuroscience Graduate Program.

Current Opinion in Neurology
|October 26, 2018
PubMed
Summary

Proteomics reveals molecular changes after traumatic brain injury (TBI), offering new insights into chronic neurological damage. This research aims to improve future TBI treatments by understanding these complex proteomic alterations.

More Related Videos

A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury
04:19

A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury

Published on: June 20, 2017

11.7K
A Novel In Vitro Model of Blast Traumatic Brain Injury
08:59

A Novel In Vitro Model of Blast Traumatic Brain Injury

Published on: December 21, 2018

11.2K

Related Experiment Videos

Last Updated: Feb 3, 2026

Controlled Cortical Impact Model for Traumatic Brain Injury
05:30

Controlled Cortical Impact Model for Traumatic Brain Injury

Published on: August 5, 2014

29.7K
A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury
04:19

A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury

Published on: June 20, 2017

11.7K
A Novel In Vitro Model of Blast Traumatic Brain Injury
08:59

A Novel In Vitro Model of Blast Traumatic Brain Injury

Published on: December 21, 2018

11.2K

Area of Science:

  • Neuroscience
  • Biochemistry
  • Proteomics

Background:

  • Chronic and progressive neurological damage after traumatic brain injury (TBI) mechanisms are not well understood, limiting treatment options.
  • Proteomics offers a novel approach to investigate alterations in the TBI proteome in both clinical and experimental settings.

Purpose of the Study:

  • To review experimental TBI models and common proteomic methods.
  • To summarize recent studies applying proteomics to TBI research.
  • To discuss the potential impact of these findings on future TBI research and patient care.

Main Methods:

  • Mass spectrometry-based proteomics approaches are increasingly standardized.
  • These methods are applied across diverse experimental models and injury types.
  • Review of recent literature applying proteomic approaches to TBI.

Main Results:

  • Emerging proteomic studies are providing insights into TBI-related molecular changes.
  • Convergence on common proteomic methods facilitates comparative analysis.
  • Application to diverse TBI models highlights the breadth of proteomic utility.

Conclusions:

  • Proteomics is a valuable tool for understanding the complex molecular landscape of TBI.
  • Recent studies demonstrate the potential of proteomic data to inform TBI treatment strategies.
  • Further research integrating proteomic findings may lead to improved patient outcomes.