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Alcohol and cancer.

A E Rogers, M W Conner

Advances in Experimental Medicine and Biology

|January 1, 1986

Summary

This summary is machine-generated.

Alcohol consumption is linked to head, neck, and liver cancers, and potentially colorectal cancers, even at low intakes. Tobacco and hepatitis B virus also play significant roles in cancer development.

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Area of Science:

Oncology
Epidemiology
Hepatology

Background:

Alcohol consumption is a known risk factor for several cancers, particularly head and neck, liver, and colorectal types.
The interplay between alcohol, tobacco use, viral infections (like Hepatitis B virus), malnutrition, and cancer development is complex.
Previous studies suggested a strong link between alcohol and liver cancer due to its association with cirrhosis.

Purpose of the Study:

To review the epidemiological and experimental evidence linking alcohol consumption to various cancers.
To explore the mechanisms by which alcohol influences carcinogenesis.
To highlight the roles of other factors like tobacco, viral infections, and malnutrition in cancer etiology.

Main Methods:

Review of epidemiological data on alcohol consumption and cancer incidence.

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Examination of experimental studies investigating alcohol's effects on carcinogenesis.

Analysis of the interaction between alcohol and other risk factors such as tobacco and viral hepatitis.

Main Results:

Alcohol is consistently associated with head and neck cancers, often co-occurring with tobacco use.
Liver cancer risk is linked to both alcohol and Hepatitis B virus, with potential synergistic effects.
Colorectal cancer association with alcohol is observed even at low intakes, particularly with beer consumption.

Conclusions:

Alcohol is a significant risk factor for multiple cancers, with varying associations depending on cancer site and other co-factors.
Understanding the complex interactions between alcohol, viruses, nutrition, and genetics is crucial for cancer prevention.
Further research, including the development of robust animal models, is needed to elucidate the mechanisms of alcohol-induced carcinogenesis.