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[Cognitive Disorders and Dementia in Old Patients With Arterial Hypertension]

O D Ostroumova1, A V Starodubova2, T M Ostroumova3

  • 1Federal State Budgetary Educational Institution of Higher Education, "A. I. Evdokimov Moscow State University for Medicine and Dentistry" of the Ministry of Health of the Russian Federation.

Kardiologiia
|October 26, 2018
PubMed

Insights

This study reviews dementia, its types, and the link between high blood pressure and cognitive decline in older adults. It examines how certain blood pressure medications may help prevent dementia.

Area of Science:

  • Neurology
  • Geriatrics
  • Cardiology

Background:

  • Dementia encompasses various conditions affecting cognitive function.
  • Arterial hypertension is a significant risk factor for cognitive disorders and dementia, particularly in the elderly.
  • Understanding the interplay between hypertension and dementia is crucial for geriatric care.

Purpose of the Study:

  • To define dementia, its diagnostic criteria, and classifications.
  • To explore the relationship between arterial hypertension and the risk of cognitive decline and dementia.
  • To evaluate the impact of antihypertensive medications on dementia risk and cognitive function.

Main Methods:

  • Review of existing literature on dementia definition, diagnosis, and classification.
  • Analysis of studies investigating the association between arterial hypertension and dementia.
  • Examination of clinical trial data on antihypertensive drugs and their effects on cognition.

Main Results:

  • Dementia presents diverse pathogenetic and clinical profiles.
  • Arterial hypertension is strongly linked to increased dementia risk in older populations.
  • Specific antihypertensive drugs, including amlodipine and indapamide-retard, show potential in dementia prevention and cognitive improvement.

Conclusions:

  • Effective management of arterial hypertension is vital for mitigating dementia risk.
  • Amlodipine and indapamide-retard demonstrate a beneficial effect on cognitive function in hypertensive patients.
  • Further research into antihypertensive therapies for dementia prevention is warranted.

Keywords:
amlodipineantihypertensive therapyarterial hypertensioncognitive disordersdementiafixed combinations of antihypertensive drugsindapamideold age

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