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Updated: Feb 3, 2026
10:08
Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound
Published on: December 2, 2014
16.5K
Aortic stiffness, pressure and flow pulsatility, and target organ damage
1Cardiovascular Engineering, Incorporated, Norwood, Massachusetts.
Journal of Applied Physiology (Bethesda, Md. : 1985)
|October 26, 2018
Summary
Increased aortic stiffness and pulsatility are linked to heart, brain, and kidney diseases. These factors contribute to excessive load on the heart and microvascular damage in vital organs.
Area of Science:
- Cardiovascular Physiology
- Nephrology
- Neurology
Background:
- Aortic stiffness and pulsatility are increasingly recognized as significant factors in cardiovascular disease.
- These hemodynamic parameters are also associated with cognitive decline (dementia) and chronic kidney disease.
- Elevated pulsatile load impacts cardiac structure and function, specifically left ventricular mass and strain.
Purpose of the Study:
- To review the evidence linking aortic stiffness to cardiovascular, brain, and kidney diseases.
- To explore the mechanisms by which aortic stiffness and pulsatility may contribute to organ damage.
Main Methods:
- This review synthesizes existing research and clinical findings.
- Evidence from epidemiological studies, clinical trials, and mechanistic investigations is considered.
Main Results:
- Higher aortic stiffness and pulsatility correlate with increased risk and progression of cardiovascular disease.
- These measures are associated with microvascular damage in the brain and kidneys.
- Excessive pulsatile load contributes to left ventricular hypertrophy and impaired function.
Conclusions:
- Aortic stiffness and pulsatility are critical determinants of health across multiple organ systems.
- Targeting aortic stiffness may offer a therapeutic strategy for preventing cardiovascular, cerebrovascular, and renal diseases.
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