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Serine/threonine kinase 32C is overexpressed in bladder cancer and contributes to tumor progression

Erlin Sun1, Kangkang Liu1, Kun Zhao1

  • 1a Department of Urology, Tianjin institute of urology , The 2nd Hospital of Tianjin Medical University , Tianjin , P.R. China.

Cancer Biology & Therapy
|October 26, 2018
PubMed

Insights

The serine/threonine kinase 32C (STK32C) is overexpressed in bladder cancer (BC) and promotes tumor growth. Silencing STK32C inhibits BC cell proliferation and invasion, suggesting it as a potential therapeutic target.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Bladder cancer (BC) biomarkers for clinical treatment remain insufficient.
  • The role of serine/threonine protein kinase 32C (STK32C) in malignancy is largely undetermined.
  • STK32C is highly expressed in brain tissues and overexpressed in BC from TCGA data.

Purpose of the Study:

  • To investigate the role and clinical significance of STK32C in bladder cancer.
  • To determine if STK32C can serve as a therapeutic target for BC.

Main Methods:

  • TCGA database analysis for STK32C expression in BC.
  • Immunohistochemistry to correlate STK32C protein levels with clinicopathologic features and relapse-free survival (RFS).
  • In vitro cell proliferation, migration, and invasion assays; in vivo tumor growth experiments; microarray analysis of the HMGB1 pathway.

Main Results:

  • High STK32C expression in BC tissues correlated with poor clinicopathologic features and shorter RFS.
  • STK32C knockdown inhibited tumor cell proliferation, migration, and invasion in vitro.
  • STK32C silencing restricted tumor growth in vivo and modulated the HMGB1 pathway.

Conclusions:

  • STK32C plays a promoting role in bladder cancer progression.
  • STK32C represents a potential novel therapeutic target for BC patients.
Keywords:
STK32CTCGAbladder cancerprogressionprotein kinase

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