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Related Concept Videos

Overview of Advanced Functional Groups02:22

Overview of Advanced Functional Groups

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Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.
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Extraction: Advanced Methods00:56

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Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
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Sample Preparation for Analysis: Advanced Techniques01:08

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Accurate analysis of complex samples often requires advanced preparation techniques to achieve reliable and reproducible results. Samples containing inorganic or organic materials can be challenging to dissolve or decompose effectively. Standard sample preparation methods include acid digestion, fusion, dry ashing, and wet digestion.
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Airway management is essential in emergency and surgical medicine, ensuring ventilation and oxygenation in patients who cannot maintain their own airway. Clinicians use a range of techniques and devices to secure the airway, depending on the patient’s condition and the clinical context. Key methods include endotracheal intubation, rapid sequence intubation (RSI), supraglottic airway devices, and advanced visualization aids. In cases where these approaches fail, surgical airway...
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Positive Regulator Molecules01:45

Positive Regulator Molecules

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To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.
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Related Experiment Video

Updated: Feb 3, 2026

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
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Advances in atopic dermatitis in 2017.

Katie Kennedy1, Jennifer Heimall2, Jonathan M Spergel2

  • 1Division of Allergy-Immunology, Children's Hospital of Philadelphia, Philadelphia, Pa.

The Journal of Allergy and Clinical Immunology
|October 26, 2018
PubMed
Summary
This summary is machine-generated.

This 2017 review highlights advances in atopic dermatitis (AD) research, focusing on the skin microbiome, molecular endotypes, and personalized biologic treatments. It covers new therapeutic insights and safety data for targeted AD therapies.

Keywords:
Atopic dermatitisbiologicseczemamicrobiometranscriptome

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Area of Science:

  • Dermatology and Immunology
  • Molecular Biology
  • Microbiome Research

Background:

  • Atopic dermatitis (AD) research in 2017 focused on understanding the skin's microenvironment and molecular patterns.
  • Key themes included the role of the microbiome, cell signaling, and symptom severity in AD pathogenesis.

Purpose of the Study:

  • To review scientific and clinical advances in atopic dermatitis (AD) published in 2017.
  • To explore emerging insights into molecular endotypes and their role in guiding personalized treatment strategies.
  • To summarize new data on targeted therapies for AD, including safety and long-term effects.

Main Methods:

  • Comprehensive review of scientific and clinical articles published in 2017.
  • Analysis of research from prominent journals, including the Journal of Allergy and Clinical Immunology.
  • Synthesis of findings related to skin microenvironment, molecular patterns, and therapeutic interventions.

Main Results:

  • Significant focus on the microbiome's influence on AD development and disease severity.
  • Identification of patient-specific molecular endotypes within the AD population.
  • Emerging data on the safety and long-term effects of newly approved targeted therapies for AD.

Conclusions:

  • Advances in understanding AD's molecular basis offer opportunities for personalized therapeutic approaches.
  • Personalized medicine strategies are being developed based on molecular endotypes and targeted interventions.
  • Continued research is crucial for optimizing novel molecularly targeted therapeutics for atopic dermatitis.