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Left ventricular dysfunction in relation with systemic inflammation in chronic obstructive pulmonary disease patients
Sule Tas Gulen1, Ufuk Eryilmaz2, Mustafa Yilmaz3
1Department of Chest Diseases, Adnan Menderes University School of Medicine, Aydin, Turkey.
The Korean Journal of Internal Medicine
|October 26, 2018
Summary
Cardiovascular disease (CVD) impacts left ventricular function in chronic obstructive pulmonary disease (COPD) patients, even before clinical symptoms appear. Echocardiographic findings correlate with COPD functional status, highlighting the link between respiratory and cardiac health.
Area of Science:
- Cardiology
- Pulmonology
- Biomarkers
Background:
- Cardiovascular disease (CVD) is a leading cause of mortality in patients with chronic obstructive pulmonary disease (COPD).
- Understanding the subclinical cardiac impact of COPD is crucial for improving patient outcomes.
Purpose of the Study:
- To assess echocardiographic parameters in COPD patients with and without pre-existing CVD.
- To investigate the relationship between echocardiographic findings and systemic inflammation markers in COPD.
Main Methods:
- Echocardiography was used to measure left and right ventricular systolic and diastolic function in 60 stable COPD patients (23 with CVD, 37 without) and 21 controls.
- Systemic inflammation markers (HsCRP, IL-8, fetuin-A, CCL-16, NT-proBNP) and functional tests (6MWT, CAT, BODE index) were evaluated.
Main Results:
- COPD patients exhibited elevated systemic inflammation and lower fetuin-A levels.
- Patients with COPD and CVD showed reduced left ventricular ejection fraction (LVEF) and increased left ventricular dimensions (LVED, LVES) compared to those without CVD.
- Aortic diameter was larger in COPD patients, and fetuin-A correlated with aortic and LVES diameters. LVEF, LVED, and LVES correlated with COPD functional parameters.
Conclusions:
- Left ventricular function is impaired in COPD patients, often preceding overt cardiac symptoms.
- Echocardiographic parameters are significantly correlated with the functional status of COPD patients, underscoring the cardiorespiratory link.
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