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[Chemoembolization].

H Nakamura, T Hashimoto, T Taguchi

    Gan to Kagaku Ryoho. Cancer & Chemotherapy
    |May 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

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    Transcatheter oily chemoembolization (TOCE) improves survival rates for unresectable hepatoma. This technique delivers high-concentration adriamycin directly to tumors, enhancing treatment effectiveness.

    Area of Science:

    • Interventional Radiology
    • Oncology
    • Hepatology

    Context:

    • Chemoembolization involves blocking tumor blood flow and delivering chemotherapy simultaneously.
    • Transcatheter oily chemoembolization (TOCE) utilizes materials like Lipiodol and adriamycin for hepatic tumors.
    • Existing treatments for unresectable hepatoma have limited survival benefits.

    Purpose:

    • To evaluate the efficacy of transcatheter oily chemoembolization (TOCE) for unresectable hepatoma.
    • To compare survival rates of TOCE with conventional hepatic embolization.
    • To assess the drug retention and slow-release characteristics of adriamycin-in-oil emulsion.

    Summary:

    • TOCE, using adriamycin-in-oil emulsion with Lipiodol, was performed on 100 patients with unresectable hepatoma.

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  • One-year survival was 53.8% and two-year survival was 36.5% in the TOCE group.
  • These rates show significant improvement compared to hepatic embolization without Lipiodol (1 year: 45.2%, 2 years: 16.3%).
  • Adriamycin-in-oil emulsion demonstrated retention within the tumor, providing a slow-release effect.

    • Impact:

    • TOCE offers a promising therapeutic option for patients with unresectable hepatoma.
    • The study highlights the synergistic effect of chemoembolization and targeted drug delivery.
    • Findings support the use of TOCE for improved patient outcomes in liver cancer treatment.