Maternal Magnesium Sulfate Supplementation in a Pre-Farrow Diet Improves Factors Important for Piglet Viability

Piglet hypoxia during farrowing is common and can lead to increased stillbirth rates, reduced piglet vitality, and an increased risk of preweaning mortality. Magnesium sulfate (MgSO₄) has successfully been used as a neuroprotectant and readily crosses the placenta in humans. Based on this human data, the aim of this study was to determine if maternal dietary supplementation with MgSO₄ prior to farrowing would reduce the impact of piglet hypoxia during the peri-natal period. Five days prior to farrowing, Large White × Landrace sows were fed either standard lactation sow diet (Cont; n = 30) or lactation diet supplemented to deliver 21 g/day MgSO₄ (Mg; n = 31). There was no effect of treatment on the percentage of stillborn piglets (p > 0.05). However, Mg piglets tended to have higher vitality scores immediately after birth (p < 0.10), were quicker to suck, and had higher day one blood glucose concentrations when compared with Cont piglets (p < 0.05). Furthermore, hypoxic piglets born to Cont sows did not gain weight from birth to 24 h, but Mg piglets did (p < 0.05), suggesting improved colostrum ingestion. In conclusion, MgSO₄ may reduce the negative impacts of birth hypoxia, improving piglet vitality, and colostrum intake during the peri-natal period.