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Updated: Feb 3, 2026

Enzymatic Synthesis of Epoxidized Metabolites of Docosahexaenoic, Eicosapentaenoic, and Arachidonic Acids
Published on: June 28, 2019
Arachidonic Acid Metabolites in Cardiovascular and Metabolic Diseases
Thomas Sonnweber1, Alex Pizzini2, Manfred Nairz3
1Department of Internal Medicine II, Medical University Innsbruck, Innsbruck 6020, Austria. Thomas.Sonnweber@i-med.ac.at.
Abstract:
Lipid and immune pathways are crucial in the pathophysiology of metabolic and cardiovascular disease. Arachidonic acid (AA) and its derivatives link nutrient metabolism to immunity and inflammation, thus holding a key role in the emergence and progression of frequent diseases such as obesity, diabetes, non-alcoholic fatty liver disease, and cardiovascular disease. We herein present a synopsis of AA metabolism in human health, tissue homeostasis, and immunity, and explore the role of the AA metabolome in diverse pathophysiological conditions and diseases.
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