Related Experiment Video
Updated: Feb 3, 2026

Detection of Protein S-Acylation using Acyl-Resin Assisted Capture
Published on: April 10, 2020
Acylated Aminooligosaccharides with Inhibitory Effects against α-Amylase from Streptomyces sp. HO1518
Hai-Li Liu1,2, Heng-Chao E3,4, Ding-An Xie5
1Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China. hlliu@sibs.ac.cn.
Abstract:
Five new acylated aminooligosaccharides (1⁻5), together with one known related analogue (6), were isolated from Streptomyces sp. HO1518. Their structure was identified by extensive spectroscopic analysis, including 1D and 2D NMR data and high resolution electrospray ionization mass spectrometry (HRESIMS), and by comparison with those reported in the literature. All of the new compounds showed more promising porcine pancreatic α-amylase (PPA) inhibitory activities than the clinical drug acarbose, indicating them as potential pharmaceutical drug leads toward type II diabetes.
More Related Videos
Related Concept Videos
Excitatory and Inhibitory Effects of Neurotransmitters
Amines to Amides: Acylation of Amines
Next, the second equivalent of amine serves as a Brønsted base and deprotonates the quaternary...
Nucleophilic Acyl Substitution of Carboxylic Acid Derivatives
Electrophilic Aromatic Substitution: Friedel–Crafts Acylation of Benzene
Buffer Effectiveness
The buffer capacity is the amount of acid or base that can be added to a given volume...
α-Alkylation of Ketones via Enolate Ions

