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Updated: Feb 3, 2026

SECONDs Administration Guidelines: A Fast Tool to Assess Consciousness in Brain-injured Patients
Published on: February 6, 2021
Thomas J Nowak1, Aaron H Lorge1, Lisa E Rein1
1Froedtert & The Medical College of Wisconsin, Milwaukee, WI, USA.
Implementing new high-dose methotrexate guidelines, which increased the supportive care discontinuation threshold to 0.1 µmol, reduced supportive care duration. This change in methotrexate protocols may allow for earlier hospital discharge.
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