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Anti-leishmanial Nanotherapeutics: A Current Perspective

Aditi Shah1, Souvik Sen Gupta1

  • 1Division of Biological and Life Sciences, School of Arts and Sciences, Ahmedabad University, Central Campus, Navrangpura, Ahmedabad, Gujarat -380009, India.

Current Drug Metabolism
|October 27, 2018
PubMed
Abstract

Insights

Nanotechnology offers promising solutions for treating leishmaniasis, a global disease. Anti-leishmanial nanotherapeutics can improve drug delivery, reduce toxicity, and overcome chemoresistance, paving the way for more effective treatments.

Area of Science:

  • Parasitology
  • Nanotechnology
  • Pharmacology

Background:

  • Leishmaniasis is a severe global disease caused by Leishmania parasites, leading to significant illness and death.
  • Current chemotherapy for leishmaniasis faces challenges including toxicity, poor bioavailability, high costs, and drug resistance.
  • The development of novel anti-leishmanial nanotherapeutics presents a potential strategy to overcome these limitations.

Purpose of the Study:

  • To review the application of nanotechnology in developing anti-leishmanial therapeutics.
  • To explore the potential of nanotherapeutics in improving drug and vaccine delivery for leishmaniasis.

Main Methods:

  • Extensive literature search of bibliographic databases for peer-reviewed articles.
  • Focus on research concerning nanotechnology in drug development, drug delivery, and vaccine delivery for anti-leishmanial applications.

Main Results:

  • Nanotechnology demonstrates significant potential in anti-leishmanial therapeutics.
  • Nanotechnology facilitates targeted drug delivery, enhancing bioavailability and reducing toxicity.
  • Application of nanotechnology can help address chemoresistance in leishmaniasis treatment.

Conclusions:

  • Anti-leishmanial nanotherapeutics show promise for effective treatment of leishmaniasis.
  • While direct nanoparticle use as therapeutics is limited, nanotechnology applications in vaccine development are emerging.
  • Nano-based drug delivery systems for leishmaniasis have advanced, holding potential to transform treatment paradigms.
Keywords:
LeishmaniaLeishmaniasisanti-leishmanial therapeuticsdrug deliverynanoparticlesnanotherapeuticsvaccine.

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