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Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

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Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
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Chronic Kidney Disease II: Clinical Manifestations01:24

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Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Chronic Kidney Disease IV: Nursing Management01:18

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Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
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Kidney Structure01:45

Kidney Structure

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The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
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Anatomy of the Ear01:16

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Auditory sensation, commonly called hearing, involves the transformation of sonic waves into neural impulses facilitated by the structures of the auditory organ. The prominent, flesh-like structure on the side of the head, called the auricle, directs sound waves towards the auditory canal. The auricle is often mislabeled as the pinna, a term more aligned with mobile structures like a feline's external ear. The auditory canal penetrates the cranium via the external auditory meatus of the...
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Polycystic Kidney-like Disease in a Red-ear Slider Turtle (Trachemys scripta elegans).

M Tecilla1, M Bielli2, F C Origgi3

  • 1University of Milan, Department of Veterinary Medicine, Via Celoria 10, Milan, Italy.

Journal of Comparative Pathology
|October 27, 2018
PubMed
Summary

A necropsy revealed polycystic kidney disease-like changes and a pancreatic cystic hamartoma in a red-ear slider turtle. This finding highlights potential developmental abnormalities in reptiles.

Keywords:
kidneypancreaspolycystic kidney-like diseaseturtle

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Area of Science:

  • Veterinary Pathology
  • Reptile Medicine
  • Developmental Biology

Background:

  • Necropsy examination of a deceased 14-year-old red-ear slider turtle (Trachemys scripta elegans) was performed.
  • The turtle had no prior history of clinical disease.

Observation:

  • Gross examination revealed esophageal prolapse, bilateral renal cysts, and a paraduodenal cystic mass.
  • Histological examination showed renal medullary cysts and atrophy resembling polycystic kidney disease (PKD).
  • The paraduodenal mass contained cysts lined by ciliated epithelial cells with positive staining for insulin and glucagon via immunohistochemistry (IHC).

Findings:

  • The renal lesions were consistent with a PKD-like disease.
  • The paraduodenal cystic mass was diagnosed as a pancreatic cystic hamartoma, characterized by embryonal-like cells expressing pancreatic hormones.
  • Immunohistochemistry for Wilm's tumour suppressor gene-1 (WT-1) showed non-specific cytoplasmic staining, and pancytokeratin expression was absent in both lesions.

Implications:

  • This case contributes to the understanding of cystic diseases in reptiles, specifically highlighting a rare pancreatic hamartoma.
  • The findings suggest potential parallels between reptilian and mammalian developmental processes and disease pathologies.
  • Further research into the etiology and pathogenesis of such cystic lesions in chelonians is warranted.