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Idiopathic central diabetes insipidus in an extreme premature infant: A case report

A Biset1, O Claris2

  • 1Department of neonatology, Hôpital Femme-Mère-Enfant, hospices Civils de Lyon, 59, boulevard Pinel, 69677 Lyon, France.

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|October 27, 2018
PubMed

Insights

Neonatal central diabetes insipidus (CDI) is hard to diagnose. Persistent hypernatremia and polyuria in newborns warrant CDI investigation and vasopressin analog treatment.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Neonatology

Background:

  • Central diabetes insipidus (CDI) is a rare neonatal condition.
  • Diagnosis is challenging due to its rarity and nonspecific symptoms in neonates.

Observation:

  • A premature infant (26 weeks gestation) presented with persistent hypernatremia and polyuria.
  • Symptoms persisted despite increased fluid intake and low sodium diet.

Findings:

  • Central diabetes insipidus was diagnosed via a therapeutic trial with an oral vasopressin analog.
  • Treatment normalized electrolyte levels, facilitating normal growth and fluid balance.

Implications:

  • Early recognition of hypernatremia and polyuria is crucial for timely CDI diagnosis in neonates.
  • Prompt treatment with vasopressin analogs can prevent complications and ensure healthy development.
Abstract

Keywords:
Central diabetes insipidusHypernatremiaNeonatePreterm

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