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Related Concept Videos

Curing of Concrete01:20

Curing of Concrete

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The hydration of cement takes place within the water-filled capillary pores. However, environmental elements can disrupt this process by evaporating water from the concrete surfaces. Sealed concrete with a water-cement ratio below 0.5 experiences self-desiccation, leading to water loss. The water loss in concrete is mitigated by curing. This technique involves keeping the concrete saturated to maintain the necessary temperature and moisture conditions, to optimally fill the spaces in the cement...
369
Curing Methods01:26

Curing Methods

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Concrete members with a small surface-to-volume ratio are cured by oiling and moistening the forms before casting the concrete member. These forms can be left in place for a prolonged period to prevent moisture loss, and can be wetted if made of a material suitable for wetting. If the forms are removed early, the concrete member is moistened and covered with polythene sheets to maintain moisture. For large horizontal concrete surfaces exposed to dry weather, a temporary covering is suspended...
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Accelerated Curing of Concrete01:25

Accelerated Curing of Concrete

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Accelerating concrete curing is achieved by applying heat and additional moisture. This process accelerates the hydration of the cement, resulting in an earlier strength gain in the concrete. Steam curing is a method wherein the concrete products are either transported through a chamber on a conveyor belt or encased in plastic, allowing steam at atmospheric pressure to circulate freely around them. This process begins with a phase of moist curing that typically lasts between 3 to 5 hours, after...
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Predicting Molecular Geometry02:27

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VSEPR Theory for Determination of Electron Pair Geometries
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Prediction Intervals01:03

Prediction Intervals

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The interval estimate of any variable is known as the prediction interval. It helps decide if a point estimate is dependable.
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y. 
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Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
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Can we predict tuberculosis cure? What tools are available?

Delia Goletti1, Cecilia S Lindestam Arlehamn2, Thomas J Scriba3

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Identifying biomarkers for tuberculosis cure can reduce lengthy treatment burdens. Early detection of patients likely to relapse-free cure or treatment failure is crucial for personalized tuberculosis therapy.

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Area of Science:

  • Medical research
  • Infectious diseases
  • Biomarker discovery

Background:

  • Tuberculosis (TB) treatment typically exceeds six months, posing a significant global health and patient burden.
  • Prolonged treatment is necessary to eliminate drug-tolerant Mycobacterium tuberculosis bacilli and prevent relapse.
  • However, many patients achieve cure with shorter treatment durations, highlighting the need for predictive assays.

Purpose of the Study:

  • To review the current state of biomarker discovery for predicting relapse-free cure in pulmonary tuberculosis.
  • To explore imaging and molecular markers that can differentiate treatment outcomes.
  • To identify needs for future research in developing reliable diagnostic tests.

Main Methods:

  • Review of existing literature on biomarkers for tuberculosis treatment response.
  • Discussion of advanced imaging techniques like positron emission tomography/computed tomography (PET/CT) for assessing pulmonary inflammation.
  • Analysis of microbiological and immunological markers under investigation.

Main Results:

  • Positron emission tomography/computed tomography (PET/CT) shows promise in evaluating pulmonary inflammation as a surrogate for cure.
  • Several microbiological and immunological markers have emerged as potentially predictive of treatment success.
  • Formal validation of these promising markers is still required.

Conclusions:

  • Biomarker discovery is essential for optimizing tuberculosis treatment duration and patient management.
  • Validated assays are needed to identify patients who can safely complete shorter treatment regimens.
  • Further research and validation are critical to develop reliable tests for personalized tuberculosis therapy.