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Updated: May 6, 2026

Primer Extension Capture: Targeted Sequence Retrieval from Heavily Degraded DNA Sources
Published on: September 3, 2009
Response to Comment on "The earliest modern humans outside Africa"
Israel Hershkovitz1,2, Mathieu Duval3,4, Rainer Grün3,5
1Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel. anatom2@post.tau.ac.il.
Abstract:
Our original claim, based on three independent numerical dating methods, of an age of ~185,000 years for the Misliya-1 modern human hemi-maxilla from Mount Carmel, Israel, is little affected by discounting uranium-series dating of adhering crusts. It confirms a much earlier out-of-Africa Homo sapiens expansion than previously suggested by the considerably younger (90,000 to 120,000 years) Skhul/Qafzeh hominins.
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